Document Detail

In vitro inhibition of 5-lipoxygenase by protolichesterinic acid from Cetraria islandica.
MedLine Citation:
PMID:  23195937     Owner:  NLM     Status:  In-Data-Review    
The aliphatic α-methylene-γ-lactone (+)-protolichesterinic acid (1), isolated from Cetraria islandica, has been shown to exhibit inhibitory effects on the enzyme 5-lipoxygenase in an in vitro assay in which porcine leucocytes are used as a source of the enzyme system. The isomeric compounds (+)-lichesterinic acid (2) and (-)-lichesterinic acid (4), prepared from (+)-protolichesterinic- and (-)-allo-protolichesterinic acids, respectively, exhibited anti-5-lipoxygenase activity of the same order of magnitude. (+)-Methyl lichesterinate (3) was, however, inactive. It was shown that despite its lipophilic nature, protolichesterinic acid is extractable into an aqueous medium, the concentration being dependent on the length of extraction.
K Ingolfsdottir; W Breu; S Huneck; G A Gudjonsdottir; B Müller-Jakic; H Wagner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Phytomedicine : international journal of phytotherapy and phytopharmacology     Volume:  1     ISSN:  0944-7113     ISO Abbreviation:  Phytomedicine     Publication Date:  1994 Dec 
Date Detail:
Created Date:  2012-11-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9438794     Medline TA:  Phytomedicine     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  187-91     Citation Subset:  -    
Copyright Information:
Copyright © 1994 Gustav Fischer Verlag, Stuttgart · Jena · New York. Published by Elsevier GmbH.. All rights reserved.
Dept. of Pharmacy, University of Iceland, 101 Reykjavik, Iceland.
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