Document Detail


In vitro and in vivo transdermal studies of atenolol using iontophoresis.
MedLine Citation:
PMID:  18536170     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Matrix formulations of Eudragit E 100: NE 40D polymers (100:0, 70:30, 60:40, 50:50% w/w) with 20% w/w of triacetine and 5% w/w of atenolol were prepared by film casting method with different solvents (methanol, 2-propanol and acetone). In vitro release of atenolol from the films were studied by vertical Franz diffusion cells in HEPES buffer (pH 7.4) for 78 h. Direct currents of 0.1 and 0.5 mA/cm2 were applied for 6 h to the formulations with Ag/AgCl electrodes. Also, transdermal application for the Eudragit E 100: NE 40 D (70:30% w/w) formulation was compared by iontophoresis or oleic acid (2.5% w/v) with control group on Wistar rats. As a result, the in vitro release rate of atenolol from films were increased with iontophoresis by increasing the current density (from 0.240 to 0.424 mg/cm2 for 70:3% w/w formulation) and also increased with the amount of Eudragit NE 40D (from 0.646 to 1.30 mg/cm2 at the end of 78 h). It is obtained from the in vivo studies that oleic acid provided a higher plasma and skin concentration (0.825 mg/mL and 12.5 mg/cm2, respectively) than iontophoresis treatment (0.399 mg/mL and 1.81 mg/cm2, respectively) due to the different mechanisms. However, the results showed that iontophoresis is a good alternative for enhancing the transdermal delivery of atenolol.
Authors:
Ozge Inal; Müge Kiliçarslan; Nuray Ari; Tamer Baykara
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta poloniae pharmaceutica     Volume:  65     ISSN:  0001-6837     ISO Abbreviation:  Acta Pol Pharm     Publication Date:    2008 Jan-Feb
Date Detail:
Created Date:  2008-06-09     Completed Date:  2008-06-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985167R     Medline TA:  Acta Pol Pharm     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  29-36     Citation Subset:  IM    
Affiliation:
Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Tandoğan, 06100, Ankara, Turkey.
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MeSH Terms
Descriptor/Qualifier:
2-Propanol / chemistry
Acetone / chemistry
Acrylates / chemistry
Administration, Cutaneous
Adrenergic beta-Antagonists / administration & dosage,  pharmacokinetics*
Animals
Atenolol / administration & dosage,  pharmacokinetics*
Diffusion
Iontophoresis*
Male
Methanol / chemistry
Oleic Acid / chemistry
Polymers / chemistry
Polymethacrylic Acids / chemistry
Rats
Rats, Wistar
Skin Absorption*
Solvents / chemistry
Triacetin / chemistry
Chemical
Reg. No./Substance:
0/Acrylates; 0/Adrenergic beta-Antagonists; 0/Eudragit E100; 0/Eudragit NE40D; 0/Polymers; 0/Polymethacrylic Acids; 0/Solvents; 102-76-1/Triacetin; 112-80-1/Oleic Acid; 29122-68-7/Atenolol; 67-56-1/Methanol; 67-63-0/2-Propanol; 67-64-1/Acetone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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