| In vitro and in vivo studies on thermistor-based intracoronary temperature measurements: effect of pressure and flow. | |
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MedLine Citation:
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PMID: 19156891 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Intracoronary thermography has been proposed to detect vulnerable plaques. We hypothesized that changes in coronary pressure and flow in the coronary tree may interfere with the temperature measurements obtained with thermistors. METHODS AND RESULTS: First, a very close correlation was found in vitro between the temperature measured by a thermocouple and by a thermistor-based temperature measuring guide wire (PressureWire, PW) over a large temperature range. Second, the PW was tested in a vitro low pressure model of "hot plaque". The sensor of the PW could detect changes in temperature of the wall of 0.5 degrees C as long as the distance from the wall was less than 0.5 mm and the flow less than 60 mL/min. Third, in 18 patients with an acute myocardial infarction, intracoronary pressure and temperature variations were assessed. Although crossing the occlusion, the temperature rose by 0.059 +/- 0.02 degrees C and this increase was correlated with the distal coronary pressure (r = 0.72, P < 0.001). Fourth, a balloon coronary occlusion (BCO) with the sensor distally in the distal part of the vessel (low flow/low pressure conditions) systematically induced an increase in temperature (0.14 +/- 0.07 degrees C) while with the sensor proximally to the balloon occlusion (low flow/normal pressure conditions), no change occurred. CONCLUSION: Taken together these observations suggest that thermistor-based sensors are not suited for assessing thermal heterogeneity in the vascular wall and that the data obtained so far in patients with acute coronary syndromes might have been flawed by pressure (and flow) artifacts. |
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Authors:
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Thomas Cuisset; Christophe Beauloye; Narbeh Melikian; Michalis Hamilos; Jaydeep Sarma; Giovanna Sarno; Maria Naslund; Leif Smith; Frans Van de Vosse; Nico H J Pijls; Bernard De Bruyne |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions Volume: 73 ISSN: 1522-726X ISO Abbreviation: Catheter Cardiovasc Interv Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-01-28 Completed Date: 2009-03-26 Revised Date: 2009-11-02 |
Medline Journal Info:
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Nlm Unique ID: 100884139 Medline TA: Catheter Cardiovasc Interv Country: United States |
Other Details:
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Languages: eng Pagination: 224-30 Citation Subset: IM |
Copyright Information:
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(c) 2009 Wiley-Liss, Inc. |
Affiliation:
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Cardiovascular Center, OLV Hospital, Aalst, Belgium. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angioplasty, Transluminal, Percutaneous Coronary / instrumentation Aorta / physiopathology Artifacts Balloon Occlusion Blood Pressure* Body Temperature* Coronary Circulation* Coronary Stenosis / complications, diagnosis, physiopathology*, therapy Coronary Vessels / physiopathology* Equipment Design Female Humans Male Middle Aged Myocardial Infarction / etiology, physiopathology*, therapy Predictive Value of Tests Regional Blood Flow Reproducibility of Results Stents Thermography / instrumentation* Time Factors |
| Comments/Corrections | |
Comment In:
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Catheter Cardiovasc Interv. 2009 Nov 1;74(5):815-6
[PMID:
19806637
]
Catheter Cardiovasc Interv. 2009 Sep 1;74(3):523-4 [PMID: 19405160 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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