| In vitro and in vivo skin anti-aging evaluation of gel containing niosomes loaded with a semi-purified fraction containing gallic acid from Terminalia chebula galls. | |
| | |
MedLine Citation:
|
PMID: 22014267 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Context: The galls of Terminalia chebula Retz. (Combretaceae) frequently appear in many Thai Lanna medicinal plant recipes for promotion of longevity. Objective: The objective of this study was to evaluate the skin anti-aging of gel containing niosomes loaded with a semi-purified fraction containing gallic acid from T. chebula galls. Method: The semi-purified fraction containing phenolic compounds including gallic acid isolated from T. chebula galls loaded in non-elastic or elastic niosomes, and its developed gel, were evaluated for rabbit skin irritation by the closed patch test and skin anti-aging in human volunteers by measuring skin elasticity and roughness. Results: Gel containing the fraction unloaded (SS) or loaded in non-elastic (SN) or elastic (SE) niosomes and gallic acid loaded in non-elastic (GN) or elastic (GE) niosomes showed no skin irritation, whereas the unloaded gallic acid (GS) gave the irritation in rabbit's skin by the closed patch test. The % parameter changes of skin elastic recovery and skin elastic extension when applied with SN and SE gels were +28.73 and +32.57; -21.25 and -22.63%, respectively. SN and SE gel also showed a significant decrease of the maximum and average roughness values with the parameter changes of -29.43 and -32.38; -39.47 and -35.28%, respectively. Conclusion: The semi-purified fraction loaded in niosomes indicated not only higher chemical stability of gallic acid containing in the fraction, but also more in vivo anti-aging activities than the unloaded fraction when incorporated in gel. |
| | |
Authors:
|
Aranya Manosroi; Pensak Jantrawut; Toshihiro Akihisa; Worapaka Manosroi; Jiradej Manosroi |
Related Documents
:
|
4898997 - Sodium-stimulated transport of glutamate in escherichia coli. 16901647 - Amino acid release at the spinomedullary junction after inflammation of the tmj region ... 9203527 - Inhibition by anion channel blockers of ischemia-evoked release of excitotoxic and othe... 6758617 - Acute effect of ethanol on metabolite concentrations of dog pancreas in vivo. 18958597 - The changes in the biochemical compositions and enzymatic activities of rotifer (brachi... 10188367 - Melanosomes of retinal pigment epithelium--distribution, shape, and acid phosphatase ac... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Pharmaceutical biology Volume: 49 ISSN: 1744-5116 ISO Abbreviation: Pharm Biol Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-10-21 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9812552 Medline TA: Pharm Biol Country: England |
Other Details:
|
Languages: eng Pagination: 1190-203 Citation Subset: IM |
Affiliation:
|
Faculty of Pharmacy, Chiang Mai University , Chiang Mai 50200 , Thailand. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ligusticum chuanxiong Hort: A review of chemistry and pharmacology.
Next Document: Protective effects of Carthamus tinctorius injection on isoprenaline-induced myocardial injury in ra...