| In vitro and in vivo safety assessment of edible blue-green algae, Nostoc commune var. sphaeroides Kützing and Spirulina plantensis. | |
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MedLine Citation:
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PMID: 21473896 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Blue-green algae (BGA)have been consumed as food and herbal medicine for centuries. However, safety for their consumption has not been well investigated. This study was undertaken to evaluate in vitro and in vivo toxicity of cultivated Nostoc commune var. sphaeroidesKützing(NO) and Spirulinaplatensis (SP). Neither NO nor SP containeddetectable levels of microcystin (MC)-LA, MC-RR, MC-LW and MC-LRby LC/MS/MS. Cell viability remained ∼70-80% when HepG2 cells were incubated with 0-500 μg/ml of hexane, chloroform, methanol and water-extractable fractions of NO and SP. Four-week-old male and female C57BL/6J mice were fed an AIN-93G/M diet supplemented with 0, 2.5% or 5% of NO and SP (wt/wt) for 6 months.For both genders, BGA-rich diets did not induce noticeable abnormality inweight gain and plasma alanine aminotransferase (ALT) and aspartate aminotransferaseconcentrations except a significant increase in plasma ALT levels by 2.5% NO supplementation in male mice at 6 month. Histopathologicalanalysis of livers, however,indicated that BGA did not cause significant liver damagecompared with controls. In conclusion, our results suggest that NO and SP are free of MC and the long-term dietary supplementation of up to 5% of the BGA may be consumed without evident toxic side-effects. |
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Authors:
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Yue Yang; Youngki Park; David A Cassada; Daniel D Snow; Douglas G Rogers; Jiyoung Lee |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-4 |
Journal Detail:
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Title: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Volume: - ISSN: 1873-6351 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8207483 Medline TA: Food Chem Toxicol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Ltd. |
Affiliation:
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Department of Nutritional Sciences, University of Connecticut, Storrs, Connecticut 06269, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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