Document Detail

In vitro and in vivo lung deposition of coated magnetic aerosol particles.
MedLine Citation:
PMID:  20845463     Owner:  NLM     Status:  MEDLINE    
The magnetic induced deposition of polydispersed aerosols composed of agglomerated superparamagnetic particles was measured with an in vitro model system and in the mouse trachea and deep lung for the purpose of investigating the potential of site specific respiratory drug delivery. Oleic acid coated superparamagnetic particles were prepared and characterized by TEM, induced magnetic moment, and iron content. The particles were dispersed in cyclohexane, aerosolized with an ultrasonic atomizer and dried by sequential reflux and charcoal columns. The fraction of iron deposited on glass tubes increased with particle size and decreasing flow rate. High deposition occurred with a small diameter tube, but the deposition fraction was largely independent of tube size at larger diameters. Results from computational fluid dynamics qualitatively agreed with the experimental results. Enhanced deposition was observed in the mouse lung but not in the trachea consistent with the analysis of the aerodynamic time allowed for deposition and required magnetic deposition time.
Yuanyuan Xie; P Worth Longest; Yun Hao Xu; Jian Ping Wang; Timothy Scott Wiedmann
Related Documents :
24632683 - The roles of surface structure, oxygen defects, and hydration in the adsorption of co2 ...
24773473 - Oxygen-vacancies confined in ultrathin indium oxide porous sheets for promoted visible-...
11257823 - The influence of microwave heating on the characteristics of polyelectrolytes.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  99     ISSN:  1520-6017     ISO Abbreviation:  J Pharm Sci     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-09-16     Completed Date:  2011-01-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4658-68     Citation Subset:  IM    
Copyright Information:
© 2010 Wiley-Liss, Inc. and the American Pharmacists Association
Department of Pharmaceutics, University of Minnesota, Minneapolis, MN, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Administration, Inhalation
Aerosols / chemistry,  pharmacokinetics*
Ferric Compounds / chemistry
Lung / metabolism*
Nanoparticles / chemistry*,  ultrastructure
Oleic Acid / chemistry*
Particle Size
Tissue Distribution
Trachea / metabolism*
Reg. No./Substance:
0/Aerosols; 0/Ferric Compounds; 112-80-1/Oleic Acid; 1309-37-1/ferric oxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Polyamine aza-cyclic compounds demonstrate anti-proliferative activity in vitro but fail to control ...
Next Document:  Water sorption, glass transition, and protein-stabilizing behavior of an amorphous sucrose matrix co...