Document Detail


In vitro and in vivo lung deposition of coated magnetic aerosol particles.
MedLine Citation:
PMID:  20845463     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The magnetic induced deposition of polydispersed aerosols composed of agglomerated superparamagnetic particles was measured with an in vitro model system and in the mouse trachea and deep lung for the purpose of investigating the potential of site specific respiratory drug delivery. Oleic acid coated superparamagnetic particles were prepared and characterized by TEM, induced magnetic moment, and iron content. The particles were dispersed in cyclohexane, aerosolized with an ultrasonic atomizer and dried by sequential reflux and charcoal columns. The fraction of iron deposited on glass tubes increased with particle size and decreasing flow rate. High deposition occurred with a small diameter tube, but the deposition fraction was largely independent of tube size at larger diameters. Results from computational fluid dynamics qualitatively agreed with the experimental results. Enhanced deposition was observed in the mouse lung but not in the trachea consistent with the analysis of the aerodynamic time allowed for deposition and required magnetic deposition time.
Authors:
Yuanyuan Xie; P Worth Longest; Yun Hao Xu; Jian Ping Wang; Timothy Scott Wiedmann
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  99     ISSN:  1520-6017     ISO Abbreviation:  J Pharm Sci     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-09-16     Completed Date:  2011-01-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4658-68     Citation Subset:  IM    
Copyright Information:
© 2010 Wiley-Liss, Inc. and the American Pharmacists Association
Affiliation:
Department of Pharmaceutics, University of Minnesota, Minneapolis, MN, USA.
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MeSH Terms
Descriptor/Qualifier:
Administration, Inhalation
Aerosols / chemistry,  pharmacokinetics*
Animals
Female
Ferric Compounds / chemistry
Lung / metabolism*
Magnetics*
Mice
Nanoparticles / chemistry*,  ultrastructure
Oleic Acid / chemistry*
Particle Size
Tissue Distribution
Trachea / metabolism*
Chemical
Reg. No./Substance:
0/Aerosols; 0/Ferric Compounds; 112-80-1/Oleic Acid; 1309-37-1/ferric oxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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