Document Detail

In vitro and in vivo lactose and lactulose effects on colonic fermentation and portal-systemic encephalopathy parameters.
MedLine Citation:
PMID:  9145447     Owner:  NLM     Status:  MEDLINE    
Lactose intolerance occurs in the majority of human groups, excluding people from Northern Europe. Because its effect is similar to that of lactulose, lactose seems to be an alternative treatment for patients with portal-systemic encephalopathy (PSE) and lactase deficiency. The mechanism of action of lactose is similar to that of lactulose. In vivo, lactose improves PSE parameters and causes acidic diarrhea. We performed in vitro studies in a fecal incubation system to investigate the biochemical and bacteriological effects induced by different substances customarily used for the treatment of patients with PSE (lactose, lactulose and Neomycin). In vitro experiments showed that lactose and lactulose decreased aerobic flora counts and reduced the pH of fecal incubation. Both disaccharides reduced the ammonia concentration in the incubation system.
M Uribe-Esquivel; S Moran; J L Poo; R M Muñoz
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Scandinavian journal of gastroenterology. Supplement     Volume:  222     ISSN:  0085-5928     ISO Abbreviation:  Scand. J. Gastroenterol. Suppl.     Publication Date:  1997  
Date Detail:
Created Date:  1997-07-16     Completed Date:  1997-07-16     Revised Date:  2008-02-13    
Medline Journal Info:
Nlm Unique ID:  0437034     Medline TA:  Scand J Gastroenterol Suppl     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  49-52     Citation Subset:  IM    
Departamento de Gastroenterología, Instituto Nacional de la Nutrición Salvador Zubirán, Tlalpan, México, D.F, México.
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MeSH Terms
Anti-Bacterial Agents / pharmacology,  therapeutic use
Colon / microbiology*
Feces / microbiology
Gastrointestinal Agents / pharmacology*,  therapeutic use
Hepatic Encephalopathy / complications,  drug therapy*,  microbiology
Lactose / pharmacology*,  therapeutic use
Lactose Intolerance / complications*
Lactulose / pharmacology*,  therapeutic use
Neomycin / pharmacology,  therapeutic use
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Gastrointestinal Agents; 1404-04-2/Neomycin; 4618-18-2/Lactulose; 63-42-3/Lactose

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