Document Detail


In vitro and in vivo evaluation of ribavirin and pleconaril antiviral activity against enterovirus 71 infection.
MedLine Citation:
PMID:  22245989     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Enterovirus 71(EV71) causes recurring outbreaks of hand, foot and mouth disease and encephalitis leading to complications or death in young children. More effective antiviral drugs are needed to prevent or reduce EV71-related disease and complications. However, there are no standard models currently in use to evaluate activity against EV71 infection both in vitro and in vivo. In this study, the activity of ribavirin and pleconaril against EV71 infection was evaluated in two models. An in vitro EV71 infection model was developed in RD cells, and an in vivo EV71 infection model was applied. Ribavirin and pleconaril effectively increased the viability of infected cells. Pleconaril reduced the morbidity and mortality of one-day-old infected mice, but ribavirin did not protect the infected mice. In all, the results demonstrated that infected cells and infected mice can be used to evaluate antiviral activity of ribavirin and pleconaril against EV71 infection in vitro and in vivo.
Authors:
Guofeng Zhang; Feng Zhou; Bin Gu; Chuanling Ding; Dongju Feng; Fangyi Xie; Jinfeng Wang; Chun Zhang; Qingxian Cao; Yinlai Deng; Weixing Hu; Kun Yao
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-15
Journal Detail:
Title:  Archives of virology     Volume:  -     ISSN:  1432-8798     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7506870     Medline TA:  Arch Virol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Microbiology and Immunity, Nanjing Medical University, 140# Hanzhong Road, Nanjing, 210029, Jiangsu, China.
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