Document Detail


In vitro and in vivo evaluation of the effects of duloxetine on P-gp function.
MedLine Citation:
PMID:  21312289     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate the effect of duloxetine (DLX) on the P-glycoprotein (P-gp) function in vitro and in vivo.
METHOD: In vitro experiment was conducted using the Caco-2 cell, a human colon cancer cell line that naturally expresses the P-gp and P-gp function was evaluated by monitoring whether DLX affect the accumulation of Rhd123. In vivo study was conducted by quantitating the effect of orally administered DLX on the bioavailability of talinolol.
RESULTS: In the in vitro study, incubation of Caco-2 cell with DLX caused a concentration-dependent increase in the accumulation of Rhd123. In the in vivo study, co-administration of DLX increased the bioavailability of talinolol. The ratio (90% confidence intervals) of AUC(0-60,) AUC(0-∞) , and C(max) (talinolol alone versus talinolol plus DLX) were 0.87(0.77-1.06), 0.85(0.74-1.01), 0.87 (0.68-1.12).
CONCLUSION: Our results suggest that DLX could inhibit the function of P-gp in vitro and in vivo, and caution should be exercised when DLX is to be co-administered with drugs that are P-gp substrate. Copyright © 2011 John Wiley & Sons, Ltd.
Authors:
Zhao Ruike; Cao Junhua; Peng Wenxing
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human psychopharmacology     Volume:  25     ISSN:  1099-1077     ISO Abbreviation:  Hum Psychopharmacol     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2011-02-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8702539     Medline TA:  Hum Psychopharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  553-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 John Wiley & Sons, Ltd.
Affiliation:
Clinical Pharmacy Research Institute, The Second Xiangya Hospital, Central South University, Changsha, PR China.
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