Document Detail


In vitro and in vivo evaluation of medicinal carbon granules and tablet on the adsorption of acetaminophen.
MedLine Citation:
PMID:  16942843     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Medicinal carbon (MC) granules were prepared by wet granulation using maltitol (MT), and the MC tablet was produced by compression of the granules. The physical properties and the in vitro adsorption capacity for AA of the formulations were examined. Further, the effects of MC alone and the granules on gastrointestinal absorption of AA were examined in rats when they were administered intragastrically at 15 or 45 min after the intragastrical administration of AA. AA was rapidly adsorbed by MC, and the maximum adsorption capacity of MC was 0.329g AA per gram MC. The granules and tablet exhibited adequate strength, and the tablet disintegrated rapidly. The granules and tablet showed similar adsorption profiles, but somewhat lower adsorption capacity than MC alone. MC alone and granules administered at 15 min reduced the AUC(0-infinity) significantly against the control (no treatment); however, the suppression effect on the plasma concentration was lower with the granules than with MC alone. Thus, granules and tablet are useful as a compact dosage form of MC; though the reduced adsorption capacity must be taken into account in order to expect efficacy equivalent to that of MC alone.
Authors:
Kenta Yamamoto; Hiraku Onishi; Akihiko Ito; Yoshiharu Machida
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Publication Detail:
Type:  Journal Article     Date:  2006-08-01
Journal Detail:
Title:  International journal of pharmaceutics     Volume:  328     ISSN:  0378-5173     ISO Abbreviation:  Int J Pharm     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-15     Completed Date:  2007-03-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7804127     Medline TA:  Int J Pharm     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  105-11     Citation Subset:  IM    
Affiliation:
Department of Drug Delivery Research, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan.
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MeSH Terms
Descriptor/Qualifier:
Acetaminophen / blood,  chemistry,  pharmacokinetics*
Adsorption
Analgesics, Non-Narcotic / blood,  chemistry,  pharmacokinetics*
Animals
Antidotes / chemistry,  pharmacology*
Charcoal / chemistry,  pharmacology*
Excipients / chemistry
Intestinal Absorption / drug effects
Male
Maltose / analogs & derivatives,  chemistry
Rats
Rats, Wistar
Sugar Alcohols / chemistry
Tablets
Chemical
Reg. No./Substance:
0/Analgesics, Non-Narcotic; 0/Antidotes; 0/Excipients; 0/Sugar Alcohols; 0/Tablets; 103-90-2/Acetaminophen; 16291-96-6/Charcoal; 585-88-6/maltitol; 69-79-4/Maltose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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