Document Detail

In vitro and in vivo comparison of argon-pumped and diode lasers for photodynamic therapy using second-generation photosensitizers.
MedLine Citation:
PMID:  9888323     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVE: Three prototype microchannel-cooled stacked diode array lasers were compared with the currently used conventional argon ion laser-pumped tunable dye lasers for suitability as light sources in photodynamic therapy (PDT) treatment.
STUDY DESIGN/MATERIALS AND METHODS: The PDT response of Chinese hamster ovary (CHO-K1) cells in culture and SMT-F tumor bearing mice treated with chloro-aluminum sulfonated phthalocyanin (CASPc), benzoporphyrin derivative mono-acid (BPD-MA), and lutetium texaphyrin (Lutex) was determined using each laser light source. Survival of the CHO cells was measured using a cloning assay. Tumor regression/eradication was used to assess response in the mice.
RESULTS: Both sources of laser light produced comparable PDT responses in the two systems tested.
CONCLUSION: It would be possible to replace the currently used argon ion laser-pumped dye laser systems with the diode lasers tested.
M J Hammer-Wilson; C H Sun; M Ghahramanlou; M W Berns
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Lasers in surgery and medicine     Volume:  23     ISSN:  0196-8092     ISO Abbreviation:  Lasers Surg Med     Publication Date:  1998  
Date Detail:
Created Date:  1999-03-22     Completed Date:  1999-03-22     Revised Date:  2013-01-24    
Medline Journal Info:
Nlm Unique ID:  8007168     Medline TA:  Lasers Surg Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  274-80     Citation Subset:  IM    
Beckman Laser Institute and Medical Clinic, University of California, Irvine 92697-1475, USA.
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MeSH Terms
Cell Line
Drug Screening Assays, Antitumor
Indoles / therapeutic use*
Laser Therapy*
Lutetium / therapeutic use*
Metalloporphyrins / therapeutic use*
Mice, Inbred DBA
Neoplasm Transplantation
Neoplasms, Experimental / drug therapy
Organometallic Compounds / therapeutic use*
Ovary / drug effects
Photochemotherapy / instrumentation*,  methods
Photosensitizing Agents / therapeutic use*
Porphyrins / therapeutic use*
Grant Support
Reg. No./Substance:
0/Indoles; 0/Metalloporphyrins; 0/Organometallic Compounds; 0/Photosensitizing Agents; 0/Porphyrins; 0/motexafin gadolinium; 0A85BJ22L6/motexafin lutetium; 104469-80-9/chloroaluminum tetrasulfophthalocyanine; 113719-89-4/benzoporphyrin D; 7439-94-3/Lutetium

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