| In vitro and in vivo comparison of argon-pumped and diode lasers for photodynamic therapy using second-generation photosensitizers. | |
MedLine Citation:
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PMID: 9888323 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVE: Three prototype microchannel-cooled stacked diode array lasers were compared with the currently used conventional argon ion laser-pumped tunable dye lasers for suitability as light sources in photodynamic therapy (PDT) treatment. STUDY DESIGN/MATERIALS AND METHODS: The PDT response of Chinese hamster ovary (CHO-K1) cells in culture and SMT-F tumor bearing mice treated with chloro-aluminum sulfonated phthalocyanin (CASPc), benzoporphyrin derivative mono-acid (BPD-MA), and lutetium texaphyrin (Lutex) was determined using each laser light source. Survival of the CHO cells was measured using a cloning assay. Tumor regression/eradication was used to assess response in the mice. RESULTS: Both sources of laser light produced comparable PDT responses in the two systems tested. CONCLUSION: It would be possible to replace the currently used argon ion laser-pumped dye laser systems with the diode lasers tested. |
Authors:
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M J Hammer-Wilson; C H Sun; M Ghahramanlou; M W Berns |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Lasers in surgery and medicine Volume: 23 ISSN: 0196-8092 ISO Abbreviation: Lasers Surg Med Publication Date: 1998 |
Date Detail:
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Created Date: 1999-03-22 Completed Date: 1999-03-22 Revised Date: 2013-01-24 |
Medline Journal Info:
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Nlm Unique ID: 8007168 Medline TA: Lasers Surg Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 274-80 Citation Subset: IM |
Affiliation:
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Beckman Laser Institute and Medical Clinic, University of California, Irvine 92697-1475, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Line Cricetinae Drug Screening Assays, Antitumor Female Indoles / therapeutic use* Laser Therapy* Lutetium / therapeutic use* Metalloporphyrins / therapeutic use* Mice Mice, Inbred DBA Neoplasm Transplantation Neoplasms, Experimental / drug therapy Organometallic Compounds / therapeutic use* Ovary / drug effects Photochemotherapy / instrumentation*, methods Photosensitizing Agents / therapeutic use* Porphyrins / therapeutic use* |
| Grant Support | |
ID/Acronym/Agency:
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2RO1CA32248/CA/NCI NIH HHS; RRO1192/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Indoles; 0/Metalloporphyrins; 0/Organometallic Compounds; 0/Photosensitizing Agents; 0/Porphyrins; 0/motexafin gadolinium; 0A85BJ22L6/motexafin lutetium; 104469-80-9/chloroaluminum tetrasulfophthalocyanine; 113719-89-4/benzoporphyrin D; 7439-94-3/Lutetium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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