Document Detail


In vitro and in vivo comparison of argon-pumped and diode lasers for photodynamic therapy using second-generation photosensitizers.
MedLine Citation:
PMID:  9888323     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND OBJECTIVE: Three prototype microchannel-cooled stacked diode array lasers were compared with the currently used conventional argon ion laser-pumped tunable dye lasers for suitability as light sources in photodynamic therapy (PDT) treatment.
STUDY DESIGN/MATERIALS AND METHODS: The PDT response of Chinese hamster ovary (CHO-K1) cells in culture and SMT-F tumor bearing mice treated with chloro-aluminum sulfonated phthalocyanin (CASPc), benzoporphyrin derivative mono-acid (BPD-MA), and lutetium texaphyrin (Lutex) was determined using each laser light source. Survival of the CHO cells was measured using a cloning assay. Tumor regression/eradication was used to assess response in the mice.
RESULTS: Both sources of laser light produced comparable PDT responses in the two systems tested.
CONCLUSION: It would be possible to replace the currently used argon ion laser-pumped dye laser systems with the diode lasers tested.
Authors:
M J Hammer-Wilson; C H Sun; M Ghahramanlou; M W Berns
Related Documents :
21508483 - Small-scale particle advection, manipulation and mixing: beyond the hydrodynamic scale.
21451713 - Cep stable 1.6 cycle laser pulses at 1.8 μm.
17182393 - Simulating the transformation of heavy metals during coal or sewage sludge combustion.
Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Lasers in surgery and medicine     Volume:  23     ISSN:  0196-8092     ISO Abbreviation:  Lasers Surg Med     Publication Date:  1998  
Date Detail:
Created Date:  1999-03-22     Completed Date:  1999-03-22     Revised Date:  2013-01-24    
Medline Journal Info:
Nlm Unique ID:  8007168     Medline TA:  Lasers Surg Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  274-80     Citation Subset:  IM    
Affiliation:
Beckman Laser Institute and Medical Clinic, University of California, Irvine 92697-1475, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Cell Line
Cricetinae
Drug Screening Assays, Antitumor
Female
Indoles / therapeutic use*
Laser Therapy*
Lutetium / therapeutic use*
Metalloporphyrins / therapeutic use*
Mice
Mice, Inbred DBA
Neoplasm Transplantation
Neoplasms, Experimental / drug therapy
Organometallic Compounds / therapeutic use*
Ovary / drug effects
Photochemotherapy / instrumentation*,  methods
Photosensitizing Agents / therapeutic use*
Porphyrins / therapeutic use*
Grant Support
ID/Acronym/Agency:
2RO1CA32248/CA/NCI NIH HHS; RRO1192/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Indoles; 0/Metalloporphyrins; 0/Organometallic Compounds; 0/Photosensitizing Agents; 0/Porphyrins; 0/motexafin gadolinium; 0A85BJ22L6/motexafin lutetium; 104469-80-9/chloroaluminum tetrasulfophthalocyanine; 113719-89-4/benzoporphyrin D; 7439-94-3/Lutetium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Photodynamic therapy with local photosensitizer delivery inhibits experimental intimal hyperplasia.
Next Document:  Psoralen and long wavelength ultraviolet radiation as an adjuvant therapy for prevention of intimal ...