Document Detail

In vitro and in vivo assessment of humic acid as an aflatoxin binder in broiler chickens.
MedLine Citation:
PMID:  16977843     Owner:  NLM     Status:  MEDLINE    
The in vitro affinity and adsorption capacity of a humic acid, oxihumate, for aflatoxin B1 (AFB1) was evaluated, utilizing Langmuir and Freundlich adsorption isotherms. Oxihumate showed a high in vitro affinity for AFB1. The Freundlich isotherm fitted the data better than the Langmuir isotherm, and binding capacities of 10.3, 7.4, and 11.9 mg of AFB1/g of oxihumate at pH 3, 5, and 7, respectively, were calculated. The in vivo efficacy of oxihumate as an aflatoxin binder in male broiler chickens exposed to aflatoxin-contaminated feed from 7 to 42 d of age was also assessed. The efficacy of oxihumate was compared with a commercially available product with a brewers dried yeast (BDY) and brewers fermentation solubles as main active ingredients. A total of 420 birds were assigned to 28 pens, with 15 birds per pen. The following treatments were applied: 1) 0 mg of AFB1 + 0 additives, 2) 1 mg of AFB1/kg of feed + 0 additives, 3) 1 mg of AFB1/kg of feed + 3.5 g of oxihumate/kg of feed, 4) 1 mg of AFB1/kg of feed + 3.5 g of BDY/kg of feed, 5) 2 mg of AFB1/kg of feed + 0 additives, 6) 2 mg of AFB1/kg of feed + 3.5 g of oxihumate/kg of feed, and 7) 2 mg of AFB1/kg of feed + 3.5 g of BDY/kg of feed. Each treatment consisted of 4 replicates. Oxihumate was effective in diminishing the adverse effects caused by aflatoxin on BW of broilers (P < 0.05). Oxihumate also showed protective effects against liver damage, stomach and heart enlargement, as well as some of the hematological and serum biochemical changes associated with aflatoxin toxicity (P < 0.05). Results indicated that oxihumate, but not BDY, could alleviate some of the toxic effects of aflatoxin in growing broilers. Oxihumate might, therefore, prove to be beneficial in the management of aflatoxin-contaminated feedstuffs for poultry when used in combination with other mycotoxin management practices. Additional studies are warranted to assess its efficacy under a wide variety of circumstances.
C Jansen van Rensburg; C E J Van Rensburg; J B J Van Ryssen; N H Casey; G E Rottinghaus
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Poultry science     Volume:  85     ISSN:  0032-5791     ISO Abbreviation:  Poult. Sci.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-09-18     Completed Date:  2006-10-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401150     Medline TA:  Poult Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1576-83     Citation Subset:  IM    
Department of Animal and Wildlife Sciences, University of Pretoria, South Africa.
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MeSH Terms
Aflatoxin B1 / chemistry*,  metabolism,  toxicity*
Animal Feed* / analysis
Chickens / metabolism*
Dose-Response Relationship, Drug
Humic Substances* / analysis
Liver / drug effects,  pathology
Mycotoxicosis / prevention & control,  veterinary*
Poultry Diseases / chemically induced*,  prevention & control
Weight Gain / drug effects
Reg. No./Substance:
0/Humic Substances; 0/oxihumate; 1162-65-8/Aflatoxin B1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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