Document Detail


In vitro and in vivo antitumor properties of tetrakis((trishydroxy- methyl)phosphine)gold(I) chloride.
MedLine Citation:
PMID:  12646023     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A novel hydrophilic gold compound, tetrakis((trishydroxymethyl)phosphine)gold(I) chloride 1, has been investigated for its antitumor properties. In vitro studies demonstrate that 1 is active against HCT-15, AGS, PC-3, and LNCaP tumor cells. Cell cycle analysis of the HCT-15 cells by flow cytometry revealed elongation of the G1 phase of the cell cycle leading to growth inhibition. Administration of 1 to Balb/C mice inoculated with syngenic meth/A cells demonstrated statistically significant dose-dependent survival time.
Authors:
Nagavarakishore Pillarsetty; Kavita K Katti; Timothy J Hoffman; Wynn A Volkert; Kattesh V Katti; Hideo Kamei; Tatsurou Koide
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of medicinal chemistry     Volume:  46     ISSN:  0022-2623     ISO Abbreviation:  J. Med. Chem.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-20     Completed Date:  2003-05-02     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  9716531     Medline TA:  J Med Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1130-2     Citation Subset:  IM    
Affiliation:
Department of Chemistry, University of Missouri-Columbia, Columbia, Missouri 65211, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antineoplastic Agents / chemical synthesis,  pharmacology*
Cell Cycle / drug effects
Dose-Response Relationship, Drug
Flow Cytometry
Magnetic Resonance Spectroscopy
Mice
Mice, Inbred BALB C
Neoplasm Transplantation
Neoplasms, Experimental / mortality
Organogold Compounds
Organometallic Compounds / chemistry,  pharmacology*
Phosphines / chemistry,  pharmacology*
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Organogold Compounds; 0/Organometallic Compounds; 0/Phosphines; 0/tetrakis((trishydroxymethyl)phosphine)gold(I)

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