| In vitro and in vivo antitrypanosomal activities of three peptide antibiotics: leucinostatin A and B, alamethicin I and tsushimycin. | |
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MedLine Citation:
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PMID: 19407848 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the course of our screening for antitrypanosomal compounds from soil microorganisms, as well as from the antibiotics library of the Kitasato Institute for Life Sciences, we found three peptide antibiotics, leucinostatin (A and B), alamethicin I and tsushimycin, which exhibited potent or moderate antitrypanosomal activity. We report here the in vitro and in vivo antitrypanosomal properties and cytotoxicities of leucinostatin A and B, alamethicin I and tsushimycin compared with suramin. We also discuss their possible mode of action. This is the first report of in vitro and in vivo trypanocidal activity of leucinostatin A and B, alamethicin I and tsushimycin. |
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Authors:
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Aki Ishiyama; Kazuhiko Otoguro; Masato Iwatsuki; Masahito Iwatsuki; Miyuki Namatame; Aki Nishihara; Kenichi Nonaka; Yuta Kinoshita; Yoko Takahashi; Rokuro Masuma; Kazuro Shiomi; Haruki Yamada; Satoshi Omura |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-05-01 |
Journal Detail:
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Title: The Journal of antibiotics Volume: 62 ISSN: 0021-8820 ISO Abbreviation: J. Antibiot. Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-06-26 Completed Date: 2009-10-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0151115 Medline TA: J Antibiot (Tokyo) Country: Japan |
Other Details:
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Languages: eng Pagination: 303-8 Citation Subset: IM |
Affiliation:
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Research Center for Tropical Diseases, Center for Basic Research, Kitasato Institute for Life Sciences and Graduate School of Infectious Control Sciences, Kitasato University, Tokyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alamethicin
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isolation & purification,
pharmacology*,
therapeutic use Animals Anti-Bacterial Agents / pharmacology*, therapeutic use Cell Line Cell Survival / drug effects Female Fermentation Lipopeptides / isolation & purification, pharmacology*, therapeutic use Mice Mice, Inbred ICR Paecilomyces / classification, metabolism* Peptides / isolation & purification, pharmacology*, therapeutic use Suramin / pharmacology Trypanocidal Agents* Trypanosoma brucei brucei / drug effects Trypanosoma brucei rhodesiense / drug effects Trypanosomiasis, African / drug therapy*, parasitology |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Lipopeptides; 0/Peptides; 0/Trypanocidal Agents; 11054-63-0/tsushimycin; 145-63-1/Suramin; 27061-78-5/Alamethicin; 76600-38-9/leucinostatin A; 76663-52-0/leucinostatin B |
| Comments/Corrections | |
Erratum In:
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J Antibiot (Tokyo). 2009 Jun;62(6):343 Note: Iwatsuki, Masahito [corrected to Iwatsuki, Masato] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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