| In vitro and in vivo antibacterial activities of garenoxacin against group G Streptococcus dysgalactiae subsp. equisimilis. | |
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MedLine Citation:
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PMID: 21726983 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In this study, garenoxacin showed potent in vitro activity against clinical isolates of group G Streptococcus dysgalactiae subsp. equisimilis [minimum inhibitory concentration for 90% of the organisms (MIC(90))=0.125μg/mL] and was superior to levofloxacin (MIC(90)=1μg/mL) and moxifloxacin (MIC(90)=0.25μg/mL). In experimental pneumonia caused by group G S. dysgalactiae subsp. equisimilis in mice, the effective dose for 50% survival (ED(50)) of garenoxacin following single oral administration was 1.87mg/kg, >10.7-fold and 4.6-fold less than the ED(50) values of levofloxacin (>20mg/kg) and moxifloxacin (8.54mg/kg), respectively. The area under the free serum concentration-time curve from 0-24h (fAUC(0-24))/MIC ratio of garenoxacin in serum following oral administration of 20mg/kg was 73.2, which was 8.7-11.4-fold and 1.4-fold greater than that of levofloxacin (6.44-8.46) and moxifloxacin (51.4), respectively. These results suggest that garenoxacin has potential for the treatment of infectious diseases caused by S. dysgalactiae subsp. equisimilis. |
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Authors:
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Masahiro Takahata; Yoko Sugiura; Yuko Shiokawa; Naoko Futakuchi; Yoshiko Fukuda; Nobuhiko Nomura; Junichi Mitsuyama |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-2 |
Journal Detail:
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Title: International journal of antimicrobial agents Volume: - ISSN: 1872-7913 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9111860 Medline TA: Int J Antimicrob Agents Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved. |
Affiliation:
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Research Laboratories, Toyama Chemical Co. Ltd., 4-1, Shimookui 2-chome, Toyama 930-8508, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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