Document Detail

In vitro and in vivo anti-photoaging effects of an isoflavone extract from soybean cake.
MedLine Citation:
PMID:  19679176     Owner:  NLM     Status:  MEDLINE    
ETHNOPHARMACOLOGICAL RELEVANCE: Soy has been used in traditional Chinese medicine for thousands of years for its health and nutritional benefits, as well as to treat and care for the skin. Advanced skin care research has shown that soy isoflavone and genistein are effective in reducing damage to the skin from the sun. AIM OF THE STUDY: To study the protective effects of isoflavone extract from soybean cake against the UVB-induced skin damage. MATERIALS AND METHODS: The in vitro effects and possible mechanisms of soybean extract on UVB protection were determined in HaCaT cells. In the in vivo study, ICR-Foxn/(nu) mice were irradiated with UVB. The epidermal thickness, catalase and the expressions of cyclooxygenase-2 (COX-2) and proliferating cell nuclear antigen (PCNA) were detected to evaluate the antioxidant and anti-inflammatory activities of the isoflavone extract. RESULTS: Our in vitro studies showed that UVB-induced HaCaT cell death and the phosphorylation of p38, JNK, and ERK1/2 decreased in the presence of isoflavone extract. In the in vivo studies, we found that the topical application of isoflavone extract before UVB irritation decreased the epidermal thickness and the expressions of COX-2 and PCNA and increased catalase concentration. These results showed anti-photoaging effect of isoflavone extract from soybean cake involved the inhibition of UVB-induced apoptosis and inflammation. CONCLUSIONS: It is shown that isoflavone extract from soybean cake may be functional cosmeceutical candidate for skin photoaging.
Tsu-Man Chiu; Chieh-Chen Huang; Tzu-Ju Lin; Jia-You Fang; Nan-Lin Wu; Chi-Feng Hung
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-08-11
Journal Detail:
Title:  Journal of ethnopharmacology     Volume:  126     ISSN:  1872-7573     ISO Abbreviation:  J Ethnopharmacol     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-19     Completed Date:  2010-02-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7903310     Medline TA:  J Ethnopharmacol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  108-13     Citation Subset:  IM    
Department of Dermatology, Changhua Christian Hospital, Changhua Hsien, Taiwan, ROC.
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MeSH Terms
Catalase / metabolism
Cell Death / drug effects
Cyclooxygenase 2 / metabolism
Drug Evaluation, Preclinical
Drugs, Chinese Herbal / chemistry,  pharmacology*
Genistein / pharmacology
Isoflavones / pharmacology*
Keratinocytes / drug effects*,  metabolism
MAP Kinase Signaling System / drug effects
Mice, Inbred ICR
Proliferating Cell Nuclear Antigen / metabolism
Skin / anatomy & histology,  blood supply,  drug effects,  metabolism
Skin Aging / drug effects*
Soybeans / chemistry*
Ultraviolet Rays
Reg. No./Substance:
0/Drugs, Chinese Herbal; 0/Isoflavones; 0/Proliferating Cell Nuclear Antigen; 446-72-0/Genistein; EC; EC 1.14.99.-/Ptgs2 protein, mouse; EC 2

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