Document Detail


In-vitro and in-vivo activities of T-3262, a new pyridone carboxylic acid.
MedLine Citation:
PMID:  3182417     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
T-3262[p-toluenesulfonic acid salt of dl-7-(3-amino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1, 4-dihydro-4-oxo-1, 8-naphthyridine-3-carboxylic acid monohydrate] is a new pyridone carboxylic acid with a broad spectrum of antibacterial activity against Gram-positive and Gram-negative bacteria. The activity of T-3262 against most Enterobacteriaceae was comparable with that of ciprofloxacin except Proteus spp. and Providencia rettgeri and exceeded that of ofloxacin and norfloxacin. The activity of T-3262 against Pseudomonas aeruginosa was comparable with that of ciprofloxacin, and T-3262 was more active than the other new quinolones against Acinetobacter calcoaceticus, Branhamella catarrhalis and Haemophilus influenzae, and also against staphylococci, streptococci, and Bacteroides fragilis. The protective effects of a single oral dose of T-3262 on systemic infection in mice were greater than norfloxacin. T-3262 was as effective as ofloxacin and ciprofloxacin against systemic infections in an animal model with Escherichia coli and Klebsiella pneumoniae, and more active against Ps. aeruginosa infections. T-3262 showed excellent activity against staphylococcal and streptococcal infections.
Authors:
M Takahata; M Otsuki; T Nishino
Related Documents :
1999237 - Gonyauline: a novel endogenous substance shortening the period of the circadian clock o...
16851897 - Ftir adsorption studies of h2o and ch3oh in the isostructural h-ssz-13 and h-sapo-34: f...
15379487 - Spreading of 16-mercaptohexadecanoic acid in microcontact printing.
3131217 - Molecular properties of elongation factor tu from streptomyces aureofaciens and escheri...
22841917 - Cognitive enhancement by omega-3 fatty acids from child-hood to old age: findings from ...
3733337 - Alteration of guinea pig erythrocyte superoxide dismutase activity by dietary antioxida...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of antimicrobial chemotherapy     Volume:  22     ISSN:  0305-7453     ISO Abbreviation:  J. Antimicrob. Chemother.     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1988-11-30     Completed Date:  1988-11-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7513617     Medline TA:  J Antimicrob Chemother     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  143-54     Citation Subset:  IM    
Affiliation:
Department of Microbiology, Kyoto Pharmaceutical University, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
4-Quinolones
Animals
Anti-Infective Agents / pharmacology*
Bacteria, Aerobic / drug effects*
Bacteria, Anaerobic / drug effects*
Drug Resistance, Microbial
Fluoroquinolones*
Hydrogen-Ion Concentration
Magnesium / pharmacology
Male
Mice
Mice, Inbred ICR
Microbial Sensitivity Tests
Naphthyridines*
Pneumonia / drug therapy
Chemical
Reg. No./Substance:
0/4-Quinolones; 0/Anti-Infective Agents; 0/Fluoroquinolones; 0/Naphthyridines; 100490-36-6/tosufloxacin; 7439-95-4/Magnesium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The in-vitro activity of PD127,391, a new quinolone.
Next Document:  Cefodizime in acute purulent exacerbations of chronic respiratory disease.