Document Detail

In-vitro and in-vivo activities of T-3262, a new pyridone carboxylic acid.
MedLine Citation:
PMID:  3182417     Owner:  NLM     Status:  MEDLINE    
T-3262[p-toluenesulfonic acid salt of dl-7-(3-amino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1, 4-dihydro-4-oxo-1, 8-naphthyridine-3-carboxylic acid monohydrate] is a new pyridone carboxylic acid with a broad spectrum of antibacterial activity against Gram-positive and Gram-negative bacteria. The activity of T-3262 against most Enterobacteriaceae was comparable with that of ciprofloxacin except Proteus spp. and Providencia rettgeri and exceeded that of ofloxacin and norfloxacin. The activity of T-3262 against Pseudomonas aeruginosa was comparable with that of ciprofloxacin, and T-3262 was more active than the other new quinolones against Acinetobacter calcoaceticus, Branhamella catarrhalis and Haemophilus influenzae, and also against staphylococci, streptococci, and Bacteroides fragilis. The protective effects of a single oral dose of T-3262 on systemic infection in mice were greater than norfloxacin. T-3262 was as effective as ofloxacin and ciprofloxacin against systemic infections in an animal model with Escherichia coli and Klebsiella pneumoniae, and more active against Ps. aeruginosa infections. T-3262 showed excellent activity against staphylococcal and streptococcal infections.
M Takahata; M Otsuki; T Nishino
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of antimicrobial chemotherapy     Volume:  22     ISSN:  0305-7453     ISO Abbreviation:  J. Antimicrob. Chemother.     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1988-11-30     Completed Date:  1988-11-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7513617     Medline TA:  J Antimicrob Chemother     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  143-54     Citation Subset:  IM    
Department of Microbiology, Kyoto Pharmaceutical University, Japan.
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MeSH Terms
Anti-Infective Agents / pharmacology*
Bacteria, Aerobic / drug effects*
Bacteria, Anaerobic / drug effects*
Drug Resistance, Microbial
Hydrogen-Ion Concentration
Magnesium / pharmacology
Mice, Inbred ICR
Microbial Sensitivity Tests
Pneumonia / drug therapy
Reg. No./Substance:
0/4-Quinolones; 0/Anti-Infective Agents; 0/Fluoroquinolones; 0/Naphthyridines; 100490-36-6/tosufloxacin; 7439-95-4/Magnesium

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