| In-vitro and in-vivo activities of T-3262, a new pyridone carboxylic acid. | |
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MedLine Citation:
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PMID: 3182417 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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T-3262[p-toluenesulfonic acid salt of dl-7-(3-amino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1, 4-dihydro-4-oxo-1, 8-naphthyridine-3-carboxylic acid monohydrate] is a new pyridone carboxylic acid with a broad spectrum of antibacterial activity against Gram-positive and Gram-negative bacteria. The activity of T-3262 against most Enterobacteriaceae was comparable with that of ciprofloxacin except Proteus spp. and Providencia rettgeri and exceeded that of ofloxacin and norfloxacin. The activity of T-3262 against Pseudomonas aeruginosa was comparable with that of ciprofloxacin, and T-3262 was more active than the other new quinolones against Acinetobacter calcoaceticus, Branhamella catarrhalis and Haemophilus influenzae, and also against staphylococci, streptococci, and Bacteroides fragilis. The protective effects of a single oral dose of T-3262 on systemic infection in mice were greater than norfloxacin. T-3262 was as effective as ofloxacin and ciprofloxacin against systemic infections in an animal model with Escherichia coli and Klebsiella pneumoniae, and more active against Ps. aeruginosa infections. T-3262 showed excellent activity against staphylococcal and streptococcal infections. |
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Authors:
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M Takahata; M Otsuki; T Nishino |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The Journal of antimicrobial chemotherapy Volume: 22 ISSN: 0305-7453 ISO Abbreviation: J. Antimicrob. Chemother. Publication Date: 1988 Aug |
Date Detail:
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Created Date: 1988-11-30 Completed Date: 1988-11-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7513617 Medline TA: J Antimicrob Chemother Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 143-54 Citation Subset: IM |
Affiliation:
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Department of Microbiology, Kyoto Pharmaceutical University, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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4-Quinolones Animals Anti-Infective Agents / pharmacology* Bacteria, Aerobic / drug effects* Bacteria, Anaerobic / drug effects* Drug Resistance, Microbial Fluoroquinolones* Hydrogen-Ion Concentration Magnesium / pharmacology Male Mice Mice, Inbred ICR Microbial Sensitivity Tests Naphthyridines* Pneumonia / drug therapy |
| Chemical | |
Reg. No./Substance:
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0/4-Quinolones; 0/Anti-Infective Agents; 0/Fluoroquinolones; 0/Naphthyridines; 100490-36-6/tosufloxacin; 7439-95-4/Magnesium |
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