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In vitro and in vivo MRS study of human glioma metabolites.
MedLine Citation:
PMID:  21528217     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
In this study an in vitro multinuclear magnetic resonance spectroscopy (MRS) characterization of water soluble metabolites and of the lipid fraction obtained from 19 human gliomas (12 glioblastomas, 3 anaplastic astrocytomas, 2 anaplastic oligodendrogliomas and 2 oligodendrogliomas) with a total of 27 surgical specimens, is reported. Moreover, some in vivo H-1 MRS results are shown. The regional metabolic heterogeneity of glioblastomas, according to their morphological heterogeneity, is documented. For glioblastomas a specific in vitro H-1 MRS metabolite profile cannot be defined. Low and high grade oligodendrogliomas showed characteristic choline/creatine and alanine/creatine metabolite ratios. The spectroscopical characterization of histopathological factors concerning malignant gliomas is shown.
Authors:
V Tugnoli; M Tosi; G Barbarella; R Ricci; F Calbucci; A Bertoluzza
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of oncology     Volume:  11     ISSN:  1019-6439     ISO Abbreviation:  Int. J. Oncol.     Publication Date:  1997 Aug 
Date Detail:
Created Date:  2011-04-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9306042     Medline TA:  Int J Oncol     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  319-24     Citation Subset:  -    
Affiliation:
CNR,IST CITOMORFOL NORMALE & PATOL,I-40136 BOLOGNA,ITALY. CNR,ICOCEA,AREA RIC,I-40129 BOLOGNA,ITALY. UNIV BOLOGNA,OSPED BELLARIA,SERV NEURORADIOL,I-40139 BOLOGNA,ITALY. UNIV BOLOGNA,OSPED BELLARIA,DIV NEUROCHIRURG,I-40139 BOLOGNA,ITALY.
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