| In vitro and in vivo MRS study of human glioma metabolites. | |
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MedLine Citation:
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PMID: 21528217 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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In this study an in vitro multinuclear magnetic resonance spectroscopy (MRS) characterization of water soluble metabolites and of the lipid fraction obtained from 19 human gliomas (12 glioblastomas, 3 anaplastic astrocytomas, 2 anaplastic oligodendrogliomas and 2 oligodendrogliomas) with a total of 27 surgical specimens, is reported. Moreover, some in vivo H-1 MRS results are shown. The regional metabolic heterogeneity of glioblastomas, according to their morphological heterogeneity, is documented. For glioblastomas a specific in vitro H-1 MRS metabolite profile cannot be defined. Low and high grade oligodendrogliomas showed characteristic choline/creatine and alanine/creatine metabolite ratios. The spectroscopical characterization of histopathological factors concerning malignant gliomas is shown. |
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Authors:
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V Tugnoli; M Tosi; G Barbarella; R Ricci; F Calbucci; A Bertoluzza |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of oncology Volume: 11 ISSN: 1019-6439 ISO Abbreviation: Int. J. Oncol. Publication Date: 1997 Aug |
Date Detail:
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Created Date: 2011-04-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9306042 Medline TA: Int J Oncol Country: Greece |
Other Details:
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Languages: eng Pagination: 319-24 Citation Subset: - |
Affiliation:
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CNR,IST CITOMORFOL NORMALE & PATOL,I-40136 BOLOGNA,ITALY. CNR,ICOCEA,AREA RIC,I-40129 BOLOGNA,ITALY. UNIV BOLOGNA,OSPED BELLARIA,SERV NEURORADIOL,I-40139 BOLOGNA,ITALY. UNIV BOLOGNA,OSPED BELLARIA,DIV NEUROCHIRURG,I-40139 BOLOGNA,ITALY. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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