| In vitro immunomodulatory effects of fractions obtained from aqueous extracts of Larrea divaricata Cav (Jarilla) on mouse peritoneal macrophages. | |
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MedLine Citation:
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PMID: 19831499 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND AIM: Larrea divaricata Cav. (Zygophyllaceae) is a plant widely used in Argentina. MATERIAL AND METHODS: We isolated different fractions of L. divaricata aqueous extract containing minor amounts of NDGA, and we analyzed these fractions on mouse macrophages. RESULTS: We showed that a fraction without NDGA was capableof activating macrophages, principally through the production of mitochondrial anion superoxide and H(2)O(2). This could be important in the defense of infections. Moreover, this fraction decreased NO level suggesting an anti-inflammatory action. CONCLUSION: These results indicate that NDGA was not the compound responsible for the immunomodulatory action exerted by the aqueous extract from L. divaricata. |
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Authors:
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Renzo F Martino; Roberto C Davicino; Mar?a A Mattar; Yolanda A Casali; Silvia G Correa; Claudia Anesini; Blas Micalizzi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Immunopharmacology and immunotoxicology Volume: 32 ISSN: 1532-2513 ISO Abbreviation: Immunopharmacol Immunotoxicol Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-19 Completed Date: 2010-05-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8800150 Medline TA: Immunopharmacol Immunotoxicol Country: England |
Other Details:
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Languages: eng Pagination: 125-32 Citation Subset: IM |
Affiliation:
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Microbiology Section, Department of Biochemistry and Biological Science, Faculty of Chemistry, Biochemistry and Pharmacy, National University of San Luis, San Luis, Argentina. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens, CD14 / analysis Apoptosis / drug effects Chromatography, Thin Layer Female Immunologic Factors / pharmacology* Larrea* / chemistry Macrophages, Peritoneal / drug effects*, metabolism Male Mice Nitric Oxide / biosynthesis Nordihydroguaiaretic Acid / pharmacology Plant Extracts / pharmacology* Reactive Oxygen Species / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD14; 0/Immunologic Factors; 0/Plant Extracts; 0/Reactive Oxygen Species; 10102-43-9/Nitric Oxide; 500-38-9/Nordihydroguaiaretic Acid |
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