| In vitro immunization for antibody production against tetanus toxin and toxoid. 3. Recombinant gamma interferon and indomethacin support specific antibody production induced by antigen-pulsed immobilized monocytes. | |
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MedLine Citation:
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PMID: 2964178 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Specific antibody production against Tetanus Toxin by in vitro cultured human peripheral blood lymphocytes may be enhanced, when monocytes were immobilized onto FCS-coated culture plates and then pulsed with Tetanus Toxoid. Using this model several immunomodulators were tested for their influence on in vitro immunization efficiency. A combination of recombinant gamma interferon and indomethacin added during antigen presentation to lymphocytes, was able to potentiate specific antibody response. |
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Authors:
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S Jahn; R Grunow; S T Kiesing; H D Volk; R von Baehr |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Allergie und Immunologie Volume: 33 ISSN: 0323-4398 ISO Abbreviation: Allerg Immunol (Leipz) Publication Date: 1987 |
Date Detail:
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Created Date: 1988-04-07 Completed Date: 1988-04-07 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0314702 Medline TA: Allerg Immunol (Leipz) Country: GERMANY, EAST |
Other Details:
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Languages: eng Pagination: 239-44 Citation Subset: IM |
Affiliation:
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Department of Medicine Charité, Humboldt-University, Berlin. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibody Formation
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drug effects* Antibody Specificity / drug effects Antigen-Presenting Cells / immunology Humans Indomethacin / administration & dosage* Interferon-gamma / administration & dosage* Interleukin-2 / administration & dosage Recombinant Proteins / administration & dosage* Tetanus Toxin / immunology* Tetanus Toxoid / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-2; 0/Recombinant Proteins; 0/Tetanus Toxin; 0/Tetanus Toxoid; 53-86-1/Indomethacin; 82115-62-6/Interferon-gamma |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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