| In-vitro glucocorticoid studies for predicting response to glucocorticoid therapy in adults with malignant lymphoma. | |
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MedLine Citation:
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PMID: 6103302 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neoplastic tissues from 28 adults with malignant lymphoma were examined for glucocorticoid receptors and in-vitro sensitivity to glucocorticoids. The patients were then treated with desamethasone for 5--14 days. 13 patients achieved at least a partial remission, and 15 had no significant tumour response. Lymphoma cells from patients who responded had more glucocorticoid-receptor sites per cell and greater in-vitro sensitivity as measured by glucocorticoid inhibition of incorporation of leucine and uridine than did tumour cells from non-responders. Study of tumour glucocorticoid receptors and glucocorticoid sensitivity in vitro may allow selection of those patients with lymphoma who should receive glucocorticoids as part of combination chemotherapy. |
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Authors:
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C D Bloomfield; K A Smith; B A Peterson; L Hildebrandt; J Zaleskas; K J Gajl-Peczalska; G Frizzera; A Munck |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Lancet Volume: 1 ISSN: 0140-6736 ISO Abbreviation: Lancet Publication Date: 1980 May |
Date Detail:
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Created Date: 1980-07-26 Completed Date: 1980-07-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985213R Medline TA: Lancet Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 952-6 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age Factors Aged Biopsy Dexamethasone / therapeutic use* Female Glucocorticoids / therapeutic use* Humans Lymph Nodes / pathology Lymphoma / analysis, drug therapy* Male Middle Aged Receptors, Glucocorticoid / analysis, drug effects* Receptors, Steroid / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 0/Receptors, Glucocorticoid; 0/Receptors, Steroid; 50-02-2/Dexamethasone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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