Document Detail


In vitro genotoxicity assays to evaluate the role of vitamin A on arsenic in human lymphocytes.
MedLine Citation:
PMID:  18499251     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ground water contamination of arsenic in drinking water is a burning problem worldwide; especially in West Bengal (India) and Bangladesh. The main endeavor in this study was to assess the role of vitamin A (2.72 microM/7 ml culture), a naturally occurring antioxidant upon arsenic-induced genotoxicity; with respect to chromosomal aberrations (structural and numerical) and micronuclei. Whole blood cultures set for 72 h were exposed to test chemicals for a period of 24 h ahead of harvesting. Arsenic concentrations tested in the present study are 0.36, 0.72 and 1.4 microM/7 ml culture. Mitomycin C (MMC), the direct acting mutagen was used as positive control. Our data indicates that at concentrations tested, arsenic-induced increase in the mean frequencies of these genotoxic indices were diminished by vitamin A, indicating its protective role towards cells from arsenic exerted injury.
Authors:
G Avani; M V Rao
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-05-21
Journal Detail:
Title:  Ecotoxicology and environmental safety     Volume:  72     ISSN:  1090-2414     ISO Abbreviation:  Ecotoxicol. Environ. Saf.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2008-12-10     Completed Date:  2009-03-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7805381     Medline TA:  Ecotoxicol Environ Saf     Country:  United States    
Other Details:
Languages:  eng     Pagination:  635-8     Citation Subset:  IM    
Affiliation:
Zoology Department, Gujarat University, Ahmedabad, India. avanigopalkrishnan@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Antioxidants / pharmacology*
Arsenic / toxicity*
Arsenic Poisoning* / drug therapy,  prevention & control
Cells, Cultured
Chromosome Aberrations / drug effects*
Humans
Lymphocytes / drug effects*
Mutagenicity Tests / methods*
Time Factors
Vitamin A / pharmacology*
Water Pollutants, Chemical / toxicity
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Water Pollutants, Chemical; 11103-57-4/Vitamin A; 7440-38-2/Arsenic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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