| In vitro generation of platelets through direct conversion: first report in My Knowledge (iMK). | |
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MedLine Citation:
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PMID: 23044804 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Blood transfusion medicine requires a constant supply of platelets, which is now totally donor dependent. Recent advances in the generation of platelets in vitro through megakaryocytes (MKs) may provide protocols not only via pluripotent stem cells, including induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs), but also via induced MKs (iMKs). For the first time, mouse and human fibroblasts are successfully transdifferentiated into iMKs by the introduction of three factors, p45NF-E2, Maf G, and Maf K. |
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Authors:
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Shigeo Masuda; Mo Li; Juan Carlos Izpisua Belmonte |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-09 |
Journal Detail:
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Title: Cell research Volume: - ISSN: 1748-7838 ISO Abbreviation: Cell Res. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9425763 Medline TA: Cell Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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