Document Detail

In vitro generation of platelets through direct conversion: first report in My Knowledge (iMK).
MedLine Citation:
PMID:  23044804     Owner:  NLM     Status:  MEDLINE    
Blood transfusion medicine requires a constant supply of platelets, which is now totally donor dependent. Recent advances in the generation of platelets in vitro through megakaryocytes (MKs) may provide protocols not only via pluripotent stem cells, including induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs), but also via induced MKs (iMKs). For the first time, mouse and human fibroblasts are successfully transdifferentiated into iMKs by the introduction of three factors, p45NF-E2, Maf G, and Maf K.
Shigeo Masuda; Mo Li; Juan Carlos Izpisua Belmonte
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Publication Detail:
Type:  Journal Article     Date:  2012-10-09
Journal Detail:
Title:  Cell research     Volume:  23     ISSN:  1748-7838     ISO Abbreviation:  Cell Res.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-04     Completed Date:  2013-08-13     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  9425763     Medline TA:  Cell Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  176-8     Citation Subset:  IM    
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MeSH Terms
3T3 Cells
Blood Platelets / cytology
Cell Line
Cell Transdifferentiation*
Fibroblasts / cytology,  metabolism
Induced Pluripotent Stem Cells / cytology
Megakaryocytes / cytology*,  metabolism
NF-E2 Transcription Factor, p45 Subunit / genetics,  metabolism
Proto-Oncogene Proteins c-maf / genetics,  metabolism
Proto-Oncogene Proteins c-myc / metabolism
Reg. No./Substance:
0/NF-E2 Transcription Factor, p45 Subunit; 0/Proto-Oncogene Proteins c-maf; 0/Proto-Oncogene Proteins c-myc

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