Document Detail

In vitro gastrointestinal model (TIM) with predictive power, even for infants and children?
MedLine Citation:
PMID:  23906665     Owner:  NLM     Status:  Publisher    
There is a need for information on the bioavailability in pediatric patients of drugs from manipulated dosage forms when applied in combination with food and/or co-medication under realistic daily practice circumstances. We describe the development, validation and application of a dynamic, computer-controlled in vitro system mimicking the conditions in the upper gastrointestinal tract of neonates, infants and toddlers: TIMpediatric. Paracetamol and diclofenac in age-related food matrices and with esomeprazole co-medication were tested. The experiments showed relevant results on the impact of drug manipulation and co-medication on the availability for absorption of active compounds. Without ethical constraints, alternative approaches for oral dosing and new pediatric formulations can be studied in TIMpediatric with a high predictive value.
Robert Havenaar; Bart Anneveld; Lidwien M Hanff; Saskia N de Wildt; Barbara A E de Koning; Miriam G Mooij; Jan P A Lelieveld; Mans Minekus
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-7-29
Journal Detail:
Title:  International journal of pharmaceutics     Volume:  -     ISSN:  1873-3476     ISO Abbreviation:  Int J Pharm     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-8-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7804127     Medline TA:  Int J Pharm     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013. Published by Elsevier B.V.
TNO, P.O. Box 360, 3700 AJ Zeist, The Netherlands. Electronic address:
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