Document Detail


In vitro gastrointestinal model (TIM) with predictive power, even for infants and children?
MedLine Citation:
PMID:  23906665     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
There is a need for information on the bioavailability in pediatric patients of drugs from manipulated dosage forms when applied in combination with food and/or co-medication under realistic daily practice circumstances. We describe the development, validation and application of a dynamic, computer-controlled in vitro system mimicking the conditions in the upper gastrointestinal tract of neonates, infants and toddlers: TIMpediatric. Paracetamol and diclofenac in age-related food matrices and with esomeprazole co-medication were tested. The experiments showed relevant results on the impact of drug manipulation and co-medication on the availability for absorption of active compounds. Without ethical constraints, alternative approaches for oral dosing and new pediatric formulations can be studied in TIMpediatric with a high predictive value.
Authors:
Robert Havenaar; Bart Anneveld; Lidwien M Hanff; Saskia N de Wildt; Barbara A E de Koning; Miriam G Mooij; Jan P A Lelieveld; Mans Minekus
Related Documents :
22047545 - Microencapsulation using vibrating technology.
21961025 - Ethnobotany in intermedical spaces: the case of the fulni-ô indians (northeastern braz...
21869655 - "teaching as a competency": competencies for medical educators.
21894285 - A competency history - an additional model of history taking.
15718195 - The importance of precision in language: communication research and (so-called) alterna...
1583485 - Impact of the black fly (diptera: simuliidae) control agent bacillus thuringiensis var....
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-7-29
Journal Detail:
Title:  International journal of pharmaceutics     Volume:  -     ISSN:  1873-3476     ISO Abbreviation:  Int J Pharm     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-8-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7804127     Medline TA:  Int J Pharm     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013. Published by Elsevier B.V.
Affiliation:
TNO, P.O. Box 360, 3700 AJ Zeist, The Netherlands. Electronic address: rob.havenaar@tno.nl.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  GATA-3 is down-regulated in patients with clear cell renal carcinoma.
Next Document:  What can we do to make antihypertensive medications taste better for children?