Document Detail

In vitro fine structural study of SIF cells and neurons in sympathetic ganglion after vinblastine treatment.
MedLine Citation:
PMID:  7148097     Owner:  NLM     Status:  MEDLINE    
Lower mesenteric ganglia of cats were rapidly excised and immediately placed in 50 ml of Eagles minimum essential medium at 37 degrees C supplemented with vinblastine sulphate (Richter) in a concentration of 2.10(-6) --10(-5) mg/ml. 35 min to 24 hours after treatment with vinblastine changes in ultrastructure of neurons, axons, and SIF cells with their processes were observed. After short time intervals of incubation with vinblastine nonspecific toxic changes in the cytoplasm of cells were observed. After 2 hours of incubation specific changes attributable to action of vinblastine were found, e.g. reduction in number of neurotubules in axons and formation of paracrystals within the axoplasm. In SIF cells no depletion of granular vesicles was found in places near the cell membrane after disassembly of SIF cell microtubules.
J Polónyi; K Kapeller; P Mráz
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Zeitschrift für mikroskopisch-anatomische Forschung     Volume:  96     ISSN:  0044-3107     ISO Abbreviation:  Z Mikrosk Anat Forsch     Publication Date:  1982  
Date Detail:
Created Date:  1983-01-19     Completed Date:  1983-01-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0413637     Medline TA:  Z Mikrosk Anat Forsch     Country:  GERMANY, EAST    
Other Details:
Languages:  eng     Pagination:  537-54     Citation Subset:  IM    
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MeSH Terms
Cytoplasmic Granules / drug effects
Ganglia, Sympathetic / drug effects*
Microscopy, Electron
Microscopy, Fluorescence
Microtubules / drug effects
Nerve Degeneration / drug effects
Neurons / drug effects
Vacuoles / drug effects
Vinblastine / pharmacology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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