| In vitro fertilization with single blastocyst-stage versus single cleavage-stage embryos. | |
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MedLine Citation:
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PMID: 16540614 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Single-embryo transfer has been recommended to reduce the incidence of multiple gestations when in vitro fertilization is performed in women under 36 years of age. We designed a prospective, randomized, controlled trial to determine whether there were any differences in the rates of pregnancy and delivery between women undergoing transfer of a single cleavage-stage (day 3) embryo and those undergoing transfer of a single blastocyst-stage (day 5) embryo. METHODS: We studied 351 infertile women under 36 years of age who were randomly assigned to undergo transfer of either a single cleavage-stage embryo (176 patients) or a single blastocyst-stage embryo (175 patients). Multifollicular ovarian stimulation was performed with a gonadotropin-releasing hormone antagonist and recombinant follicle-stimulating hormone. RESULTS: The study was terminated early after a prespecified interim analysis (which included 50 percent of the planned number of patients) found a higher rate of pregnancy among women undergoing transfer of a single blastocyst-stage embryo (P=0.02). The rate of delivery was also significantly higher in this group than in the group undergoing transfer of a single cleavage-stage embryo (32.0 percent vs. 21.6 percent; relative risk, 1.48; 95 percent confidence interval, 1.04 to 2.11). Two multiple births occurred, both of monozygotic twins, both of which were in the group undergoing transfer of a single cleavage-stage embryo. CONCLUSIONS: These findings support the transfer of a single blastocyst-stage (day 5) embryo in infertile women under 36 years of age. |
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Authors:
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Evangelos G Papanikolaou; Michel Camus; Efstratios M Kolibianakis; Lisbet Van Landuyt; Andre Van Steirteghem; Paul Devroey |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: The New England journal of medicine Volume: 354 ISSN: 1533-4406 ISO Abbreviation: N. Engl. J. Med. Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-03-16 Completed Date: 2006-03-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0255562 Medline TA: N Engl J Med Country: United States |
Other Details:
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Languages: eng Pagination: 1139-46 Citation Subset: AIM; IM |
Copyright Information:
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Copyright 2006 Massachusetts Medical Society. |
Affiliation:
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Centre for Reproductive Medicine, Academisch Ziekenhuis, Vrije Universiteit Brussel, Brussels. evangelos.papanikolaou@vub.ac.be |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blastocyst* Cleavage Stage, Ovum* Embryo Culture Techniques Embryo Transfer* Female Fertilization in Vitro / methods* Humans Live Birth Ovulation Induction / methods Pregnancy Pregnancy, Multiple Prospective Studies |
| Comments/Corrections | |
Comment In:
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N Engl J Med. 2006 Mar 16;354(11):1190-3
[PMID:
16540622
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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