Document Detail

In vitro fertilization with preimplantation genetic screening.
MedLine Citation:
PMID:  17611204     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Pregnancy rates in women of advanced maternal age undergoing in vitro fertilization (IVF) are disappointingly low. It has been suggested that the use of preimplantation genetic screening of cleavage-stage embryos for aneuploidies may improve the effectiveness of IVF in these women. METHODS: We conducted a multicenter, randomized, double-blind, controlled trial comparing three cycles of IVF with and without preimplantation genetic screening in women 35 through 41 years of age. The primary outcome measure was ongoing pregnancy at 12 weeks of gestation. The secondary outcome measures were biochemical pregnancy, clinical pregnancy, miscarriage, and live birth. RESULTS: Four hundred eight women (206 assigned to preimplantation genetic screening and 202 assigned to the control group) underwent 836 cycles of IVF (434 cycles with and 402 cycles without preimplantation genetic screening). The ongoing-pregnancy rate was significantly lower in the women assigned to preimplantation genetic screening (52 of 206 women [25%]) than in those not assigned to preimplantation genetic screening (74 of 202 women [37%]; rate ratio, 0.69; 95% confidence interval [CI], 0.51 to 0.93). The women assigned to preimplantation genetic screening also had a significantly lower live-birth rate (49 of 206 women [24%] vs. 71 of 202 women [35%]; rate ratio, 0.68; 95% CI, 0.50 to 0.92). CONCLUSIONS: Preimplantation genetic screening did not increase but instead significantly reduced the rates of ongoing pregnancies and live births after IVF in women of advanced maternal age. (Current Controlled Trials number, ISRCTN76355836 [].).
Sebastiaan Mastenbroek; Moniek Twisk; Jannie van Echten-Arends; Birgit Sikkema-Raddatz; Johanna C Korevaar; Harold R Verhoeve; Niels E A Vogel; Eus G J M Arts; Jan W A de Vries; Patrick M Bossuyt; Charles H C M Buys; Maas Jan Heineman; Sjoerd Repping; Fulco van der Veen
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2007-07-04
Journal Detail:
Title:  The New England journal of medicine     Volume:  357     ISSN:  1533-4406     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-07-05     Completed Date:  2007-07-10     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  9-17     Citation Subset:  AIM; IM    
Copyright Information:
Copyright 2007 Massachusetts Medical Society.
Center for Reproductive Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
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MeSH Terms
Birth Rate
Chromosome Disorders / diagnosis*
Double-Blind Method
Embryo Transfer
Fertilization in Vitro*
Follow-Up Studies
Genetic Testing* / methods
In Situ Hybridization, Fluorescence
Maternal Age
Pregnancy Outcome
Pregnancy Rate*
Preimplantation Diagnosis* / adverse effects
Sperm Injections, Intracytoplasmic
Comment In:
N Engl J Med. 2007 Oct 25;357(17):1769-70; author reply 1770-1   [PMID:  17960019 ]
N Engl J Med. 2007 Jul 5;357(1):61-3   [PMID:  17611209 ]
N Engl J Med. 2007 Oct 25;357(17):1770; author reply 1770-1   [PMID:  17969227 ]
N Engl J Med. 2007 Oct 25;357(17):1770; author reply 1770-1   [PMID:  17969226 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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