Document Detail

In vitro fertilization and pregnancy rates: the influence of sperm motility and morphology on IVF outcome.
MedLine Citation:
PMID:  9696226     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the relationship between sperm motility and sperm morphology parameters and IVF and pregnancy rates. DESIGN: Pre- and postpreparation analysis of semen samples from infertile couples undergoing IVF-ET. SETTING: Andrology Laboratory, Royal Maternity Hospital, Belfast, Northern Ireland. PATIENT(S): One hundred fifty couples undergoing IVF-ET treatment at the Regional Fertility Centre. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): The ability of human sperm to achieve IVF and pregnancy was investigated in relation to motility parameters (assessed with computer-aided sperm analysis [Integrated Visual Optical System] and percent normal morphology (determined with the strict criteria). RESULT(S): Significant differences were observed in motility parameters and percent normal morphology in samples that achieved > or =50% fertilization compared with < or =50% fertilization and between samples that achieved a pregnancy compared with those that did not. Significant positive correlations were observed between percent progressive motility, the velocity of sperm movement, and morphology parameters and both IVF and pregnancy. CONCLUSION(S): Both sperm motility parameters and percent normal morphology are significant factors in predicting fertilization and pregnancy rates in IVF.
E T Donnelly; S E Lewis; J A McNally; W Thompson
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Fertility and sterility     Volume:  70     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1998-08-27     Completed Date:  1998-08-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  305-14     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, The Queen's University of Belfast, Northern Ireland.
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MeSH Terms
Diagnosis, Computer-Assisted
Embryo Transfer*
Fertilization in Vitro*
Pregnancy Rate*
Sperm Head / physiology,  ultrastructure
Sperm Motility / physiology*
Spermatozoa / ultrastructure
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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