Document Detail

In-vitro fertilization and intracytoplasmic sperm injection in the treatment of infertility after testicular cancer.
MedLine Citation:
PMID:  9557849     Owner:  NLM     Status:  MEDLINE    
Treatment of testicular cancer (TC) may cause infertility due to reduced sperm quality with or without an ejaculation problem. In cases of anejaculation or retrograde ejaculation, spermatozoa can be obtained by transrectal electroejaculation (TE) or testicular sperm extraction (TESE) and used for in-vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI). In this study, 15 out of 17 couples evaluated for infertility after TC, underwent a total of 21 treatment cycles, resulting in 18 embryo transfers. Spermatozoa were obtained by TE in 16 cycles, by masturbation in three cycles and by TESE in one. In one cycle no spermatozoa were found using TESE. Fertilization and cleavage was achieved by IVF in seven cycles and ICSI in 11 cycles; average fertilization rates of 57 and 55% respectively were observed. Twelve clinical pregnancies occurred, of which 11 have been delivered or are ongoing. The ongoing pregnancy rate was 57% per cycle. These results show that infertility after testicular cancer can be treated effectively with IVF and that ICSI even permits treatment of patients who have severe oligozoospermia.
B Rosenlund; P Sjöblom; M Törnblom; C Hultling; T Hillensjö
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  13     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-06-15     Completed Date:  1998-06-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  414-8     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, Huddinge University Hospital, Karolinska Institute, Sweden.
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MeSH Terms
Electric Stimulation
Embryo Transfer
Fertilization in Vitro / methods*
Infertility, Male / etiology*,  therapy*
Testicular Neoplasms / therapy*
Testis / pathology,  surgery

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