Document Detail

In vitro fertilization and intracytoplasmic sperm injection for couples with unexplained infertility after failed direct intraperitoneal insemination.
MedLine Citation:
PMID:  11155325     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The objective was to determine the optimal insemination technique in patients undergoing in vitro fertilization (IVF) after failed direct intraperitoneal insemination (DIPI) and the outcome of intracytoplasmic sperm injection (ICSI) in such cases.
METHODS: In case-control studies, 53 couples with unexplained infertility who underwent IVF after four failed DIPI cycles were compared with 75 couples with tubal or endometriosis infertility as controls. Thirty couples with unexplained infertility after failing to conceive with DIPI and conventional IVF who underwent ICSI and 58 couples with male-factor infertility as controls also were compared. Fertilization cleavage, embryo quality, implantation, and pregnancy were compared after IVF and after ICSI.
RESULTS: There was a significant difference in fertilization rates after IVF between cases of unexplained infertility after failing to conceive with DIPI (40.4%) and patients with tubal or endometriosis infertility (67.9%). There also was a significant difference in total fertilization failure rates between the two groups (30.4% and 3.9%, respectively). There was a slight but significant difference in numbers of fertilized oocytes after ICSI between patients with low fertilization rate undergoing IVF after failing to conceive DIPI (85.8%) and patients with male factor (90.4%). Total fertilization failure was not observed in these cases.
CONCLUSIONS: Couples with unexplained infertility after failing to conceive with DIPI show a failed fertilization or a low fertilization rate after IVF. However, they demonstrated a good chance of becoming pregnant after subsequent ICSI, even with statistically significant difference in fertilization rate as compared with male-factor cases.
S Takeuchi; H Minoura; T Shibahara; X Shen; N Futamura; N Toyoda
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of assisted reproduction and genetics     Volume:  17     ISSN:  1058-0468     ISO Abbreviation:  J. Assist. Reprod. Genet.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2001-01-11     Completed Date:  2001-03-29     Revised Date:  2013-03-07    
Medline Journal Info:
Nlm Unique ID:  9206495     Medline TA:  J Assist Reprod Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  515-20     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Mie University School of Medicine, Mie, Japan.
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MeSH Terms
Embryo, Mammalian / physiology
Infertility / etiology,  therapy*
Insemination, Artificial / methods
Oocytes / physiology
Ovulation Induction
Pregnancy Rate
Sperm Injections, Intracytoplasmic*
Treatment Failure

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