Document Detail

In vitro fertilization of in vitro matured oocytes obtained from the follicles without hCG exposure for prevention of severe ovarian hyperstimulation syndrome: a case report.
MedLine Citation:
PMID:  8624895     Owner:  NLM     Status:  MEDLINE    
We aspirated ovarian follicles of an infertile patient who encountered a great risk of ovarian hyperstimulation (OHSS) during her ovulation-induction cycle, which had been stimulated with gonadotropins, in order to avoid OHSS without interrupting the treatment. If this action were to yield a considerable number of immature oocytes, some of which were to achieve in vitro maturation and subsequent fertilization, this method could be an alternative to conventional ovulation-induction methods for patients who repeatedly present imminent signs of hyperstimulation. However, the number of oocytes collected from the patient was disappointingly low, even though a large number of follicles were thoroughly aspirated. One of these oocytes was matured in vitro in a medium containing 30% follicular fluid and granulosa cells of mature follicles, fertilized, cryopreserved, and transferred in a later artificial cycle; but pregnancy was not achieved. A low number of recovered oocytes from patients in this situation might be a factor that greatly limits the clinical applications of this method.
H Kodama; J Fukuda; H Karube; T Matsui; Y Shimizu; T Tanaka
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The journal of obstetrics and gynaecology research     Volume:  22     ISSN:  1341-8076     ISO Abbreviation:  J. Obstet. Gynaecol. Res.     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-06-21     Completed Date:  1996-06-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9612761     Medline TA:  J Obstet Gynaecol Res     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  61-5     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Akita University School of Medicine, Japan.
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MeSH Terms
Fertilization in Vitro / methods*
Infertility, Female / therapy*
Ovarian Hyperstimulation Syndrome / etiology,  prevention & control*
Ovulation Induction / methods*
Specimen Handling / methods

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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