| In vitro fermentation of a red wine extract by human gut microbiota: changes in microbial groups and formation of phenolic metabolites. | |
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MedLine Citation:
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PMID: 22313337 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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An in vitro batch culture fermentation experiment was conducted with faecal inocula from three healthy volunteers in the presence and absence of a red wine extract. Changes in main bacterial groups were determined by FISH during a 48 h fermentation period. The catabolism of main flavonoids (i.e., flavan-3-ols and anthocyanins) and the formation of wide a range of phenolic microbial metabolites were determined by a targeted UPLC-PAD-ESI-TQ MS method. Statistical analysis revealed that catechol/pyrocatechol, as well as 4-hydroxy-5-(phenyl)-valeric, 3- and 4-hydroxyphenylacetic, phenylacetic, phenylpropionic, and benzoic acids showed the greatest increases observed during fermentation, whereas 5-(3'-hydroxyphenyl)--valerolactone, its open form 4-hydroxy-5-(3'-hydroxyphenyl)-valeric acid and 3,4-dihydroxyphenylacetic acid represented the largest inter-individual variations in the catabolism of red wine polyphenols. Despite these changes, microbial metabolism did not produce significant changes in the main bacterial groups detected although a slight inhibition of the Clostridium histolyticum group was observed. |
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Authors:
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Fernando Sanchez-Patan; Carolina Cueva; Maria Monagas; Gemma E Walton; Glenn R Gibson; Rosa Lebrón-Aguilar; Jesus E Quintanilla; Pedro J Martin-Alvarez; M Victoria Moreno-Arribas; Begoña Bartolome |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-7 |
Journal Detail:
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Title: Journal of agricultural and food chemistry Volume: - ISSN: 1520-5118 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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