Document Detail


In vitro experiments on neuronal and glial cell lineages among the ventricular cells of the mouse neural plate.
MedLine Citation:
PMID:  2711864     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The proliferative ventricular cells of the early neural plate of the mouse are generally assumed to be pluripotent and equivalent to one another in their developmental capability. Ventricular cells from the rostral parts of the neural plates of mice (Theiler stages 11 and 12, embryonic days 71/2 and 8) were studied in tissue culture with respect to their potential to give rise to neurons or glial cells, or both. Autoradiographic and immunohistochemical analyses showed that ventricular cells developing into neuronal phenotypes stopped proliferating immediately upon transfer to cell culture. Using polyclonal anti-GFAP antibodies, a small proportion of immunoreactive cells could be detected after 4 days of culture. These cells retained their proliferative activity, displayed morphological characteristics of radial glial cells, and may have either developed from specific glial progenitor cells or have been induced to proceed along the glial differentiation pathway at the beginning of culture. Therefore, two distinct types of progenitor cells, committed either to neuronal or glial lineages, appear to co-exist among the cultured neural plate ventricular cells.
Authors:
E Buse; A Kindler-Röhrborn; M F Rajewsky
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience     Volume:  7     ISSN:  0736-5748     ISO Abbreviation:  Int. J. Dev. Neurosci.     Publication Date:  1989  
Date Detail:
Created Date:  1989-05-26     Completed Date:  1989-05-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8401784     Medline TA:  Int J Dev Neurosci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  103-13     Citation Subset:  IM    
Affiliation:
Anatomisches Institut, Universität Kiel, F.R.G.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies, Monoclonal / diagnostic use
Astrocytes / cytology,  metabolism,  physiology*
Cell Differentiation
Cell Division
Cerebral Ventricles / cytology,  embryology*
Glial Fibrillary Acidic Protein / metabolism
Immunohistochemistry
Mice
Neurons / cytology,  metabolism,  physiology*
Thymidine / diagnostic use
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Glial Fibrillary Acidic Protein; 50-89-5/Thymidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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