| In vitro evaluations of transdermal levonorgestrel. | |
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MedLine Citation:
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PMID: 2127673 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Transdermal delivery systems were prepared and evaluated for their ability to co-deliver the contraceptive agent levonorgestrel and the penetration enhancer ethyl acetate across hairless guinea pig, hairless mouse, and rat skin. The 24 hr devices were prepared with membranes composed of ethylene vinyl acetate [EVAc, 7.5% vinyl acetate (VAc) content] copolymers, and blends of EVAc (7.5% VAc content) and poly(methyl methacrylate) or poly(ethyl methacrylate). The reservoir phase (levonorgestrel-saturated ethyl acetate gelled with 2 wt% hydroxypropyl cellulose) was also evaluated for drug and solvent delivery with each of the rodent skins. Devices were also tested in which levonorgestrel was suspended in the adhesive. The results indicate that all the devices deliver levonorgestrel and the enhancer at about the same rate regardless of the skin type. It appears that the flux of LN follows the flux of EtAc until the devices are nearly depleted of EtAc, when delivery of LN remains relatively high. |
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Authors:
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P Catz; D R Friend |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Drug design and delivery Volume: 6 ISSN: 0884-2884 ISO Abbreviation: Drug Des. Deliv. Publication Date: 1990 May |
Date Detail:
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Created Date: 1991-05-01 Completed Date: 1991-05-01 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8712388 Medline TA: Drug Des Deliv Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 49-60 Citation Subset: IM |
Affiliation:
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Controlled Release and Biomedical Polymers Department, SRI International, Menlo Park, California 94025. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetates Administration, Cutaneous Animals Chromatography, High Pressure Liquid Delayed-Action Preparations Diffusion Guinea Pigs Levonorgestrel Membranes, Artificial Mice Mice, Hairless Norgestrel / administration & dosage* Rats |
| Grant Support | |
ID/Acronym/Agency:
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N01-HD-5-2911/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Acetates; 0/Delayed-Action Preparations; 0/Membranes, Artificial; 141-78-6/ethyl acetate; 6533-00-2/Norgestrel; 797-63-7/Levonorgestrel |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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