Document Detail


In vitro evaluations of transdermal levonorgestrel.
MedLine Citation:
PMID:  2127673     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Transdermal delivery systems were prepared and evaluated for their ability to co-deliver the contraceptive agent levonorgestrel and the penetration enhancer ethyl acetate across hairless guinea pig, hairless mouse, and rat skin. The 24 hr devices were prepared with membranes composed of ethylene vinyl acetate [EVAc, 7.5% vinyl acetate (VAc) content] copolymers, and blends of EVAc (7.5% VAc content) and poly(methyl methacrylate) or poly(ethyl methacrylate). The reservoir phase (levonorgestrel-saturated ethyl acetate gelled with 2 wt% hydroxypropyl cellulose) was also evaluated for drug and solvent delivery with each of the rodent skins. Devices were also tested in which levonorgestrel was suspended in the adhesive. The results indicate that all the devices deliver levonorgestrel and the enhancer at about the same rate regardless of the skin type. It appears that the flux of LN follows the flux of EtAc until the devices are nearly depleted of EtAc, when delivery of LN remains relatively high.
Authors:
P Catz; D R Friend
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Drug design and delivery     Volume:  6     ISSN:  0884-2884     ISO Abbreviation:  Drug Des. Deliv.     Publication Date:  1990 May 
Date Detail:
Created Date:  1991-05-01     Completed Date:  1991-05-01     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8712388     Medline TA:  Drug Des Deliv     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  49-60     Citation Subset:  IM    
Affiliation:
Controlled Release and Biomedical Polymers Department, SRI International, Menlo Park, California 94025.
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MeSH Terms
Descriptor/Qualifier:
Acetates
Administration, Cutaneous
Animals
Chromatography, High Pressure Liquid
Delayed-Action Preparations
Diffusion
Guinea Pigs
Levonorgestrel
Membranes, Artificial
Mice
Mice, Hairless
Norgestrel / administration & dosage*
Rats
Grant Support
ID/Acronym/Agency:
N01-HD-5-2911/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Acetates; 0/Delayed-Action Preparations; 0/Membranes, Artificial; 141-78-6/ethyl acetate; 6533-00-2/Norgestrel; 797-63-7/Levonorgestrel

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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