Document Detail


In vitro evaluation of vascular endothelial growth factor (VEGF)-eluting stents.
MedLine Citation:
PMID:  14659860     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Vascular endothelial growth factor (VEGF) is a specific endothelial cell mitogen. It promotes re-endothelialisation of the damaged vessel surface seen after stenting. Stent thrombosis and in-stent restenosis are partly related to endothelial denudation caused by stent implantation. We propose using hydrocarbon polymer-coated stents immersed in VEGF to speed re-endothelialisation and reduce the risk of stent thrombosis and restenosis. METHODS: Stents (3 x 20 mm) were immersed in VEGF solutions and maximal VEGF absorption calculated. VEGF release from these stents was measured in a perfusion circuit. Delivery of VEGF to arterial wall was measured. Sterile VEGF-loaded stents were cultured with human umbilical vein endothelial cells. RESULTS: 18.5 +/- 4.1 microg VEGF was absorbed, 80% of which was released over 9 days; 11 +/- 6.8% of the initial VEGF loaded was delivered to the vessel wall. Cells exposed to VEGF-eluting stents showed an 11% increase in growth relative to controls. CONCLUSION: VEGF may be a candidate for stent-based delivery and may increase the rate of endothelialisation in vivo.
Authors:
Neil Swanson; Kai Hogrefe; Qamar Javed; Anthony H Gershlick
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of cardiology     Volume:  92     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-12-08     Completed Date:  2004-04-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  247-51     Citation Subset:  IM    
Affiliation:
University of Leicester, Cardiology Clinical Sciences, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK. ns56@le.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Cells, Cultured
Coronary Stenosis
Endothelium, Vascular / growth & development
Equipment Design
Humans
Stents*
Vascular Endothelial Growth Factor A / administration & dosage*,  pharmacology
Chemical
Reg. No./Substance:
0/Vascular Endothelial Growth Factor A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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