| In vitro evaluation of poly[bis(ethyl alanato)phosphazene] as a scaffold for bone tissue engineering. | |
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MedLine Citation:
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PMID: 16674294 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Polyphosphazenes with amino acid ester as side groups are biocompatible polymers that could provide valid scaffolds for cell growth. In the present study we investigate the adhesion and growth of osteoblasts obtained from rat bone marrow on matrices composed of thin fibers of poly[bis(ethyl alanato)phosphazene] (PAlaP), poly(d,l-lactic acid) (PDLLA), or PAlaP/PDLLA blend. Our data show that scaffolds of PAlaP or PAlaP/PDLLA blend enhanced the cell adhesion and growth in comparison with that observed in cultures seeded on polystyrene tissue culture plates. Although collagenase-digestible protein synthesis remained unchanged, all scaffolds induced a decrease in alkaline phosphatase activity, suggesting that osteoblasts are in the proliferation phase. Both PAlaP and PAlaP blended with PDLLA may represent a new and interesting substrate for bone tissue engineering. |
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Authors:
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Maria Teresa Conconi; Silvano Lora; Anna Michela Menti; Paolo Carampin; Pier Paolo Parnigotto |
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Publication Detail:
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Type: Evaluation Studies; In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Tissue engineering Volume: 12 ISSN: 1076-3279 ISO Abbreviation: Tissue Eng. Publication Date: 2006 Apr |
Date Detail:
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Created Date: 2006-05-05 Completed Date: 2006-07-13 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9505538 Medline TA: Tissue Eng Country: United States |
Other Details:
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Languages: eng Pagination: 811-9 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Sciences, University of Padua, Padua, Italy. mariateresa.conconi@unipd.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alkaline Phosphatase
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analysis Animals Biocompatible Materials / chemistry* Bone and Bones* Calcium Phosphates / metabolism Cells, Cultured Evaluation Studies as Topic Organophosphorus Compounds / chemistry* Osteoblasts / cytology, enzymology, metabolism, ultrastructure Osteocalcin / analysis Polymers / chemistry* Rats Rats, Sprague-Dawley Tissue Engineering / methods* |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 0/Calcium Phosphates; 0/Organophosphorus Compounds; 0/Polymers; 0/poly(phosphazene); 10103-46-5/calcium phosphate; 104982-03-8/Osteocalcin; EC 3.1.3.1/Alkaline Phosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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