Document Detail

In vitro evaluation of the oxidation efficacy of transgingival photodynamic therapy.
MedLine Citation:
PMID:  23320555     Owner:  NLM     Status:  Publisher    
Abstract Objective. To evaluate the capability of soft laser light to penetrate blood, serum, gingival connective tissue and pure collagen type I. Materials and methods. A 1:1 mixture of methylene blue (MB) and diphenylisobenzofuran (DPBF) was irradiated for 60 s with a diode laser (670 nm, 0.3 W) through blood, serum, gingival connective tissue and collagen type I (2 mm transillumination thickness). The oxidation of DPBF by MB was determined spectrophotometrically by measuring the optical density (oD) at 410 nm. The absorption spectra of DPBF/MB irradiated through MB (1%) and strawberry red solution (3%) served as control. Results. The mean oD of non-irradiated DPBF/MB was 1.98 ± 0.04. Irradiation through MB showed no oxidation of DPBF (1.98 ± 0.02; p > 0.05), while interposition of strawberry red and serum resulted in almost complete oxidation of DPBF (0.13 ± 0.09, 0.06 ± 0.03; p ≤ 0.0001). Irradiation through gingiva and collagen reduced the oxidation of DPBF significantly (1.0 ± 0.04, 0.7 ± 0.04; p ≤ 0.0001), accounting for 50% to 35% of the non-irradiated DPBF/MB solution. Conclusion. Red light from a diode laser can penetrate blood and gingival tissues. However, light absorption for collagen and connective tissue can hamper the oxidation process.
Valerie Ronay; Wolfgang Buchalla; Philipp Sahrmann; Thomas Attin; Patrick R Schmidlin
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-16
Journal Detail:
Title:  Acta odontologica Scandinavica     Volume:  -     ISSN:  1502-3850     ISO Abbreviation:  Acta Odontol. Scand.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370344     Medline TA:  Acta Odontol Scand     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Clinic for Preventive Dentistry, Cariology and Periodontology, Center for Dental Medicine, University of Zurich , Switzerland.
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