Document Detail


In vitro evaluation of a novel orally administered cephalosporin (Cefditoren) tested against 1249 recent clinical isolates of Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pneumoniae.
MedLine Citation:
PMID:  9764398     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cefditoren (formerly ME-1206), a new orally administered cephalosporin, was evaluated in vitro against 1249 recently isolated strains of Streptococcus pneumoniae (500 strains), Moraxella catarrhalis (250 strains), and Haemophilus influenzae (499 strains). Reference National Committee for Clinical Laboratory Standards methods were used and the strains were representative for the current rates of beta-lactamase production or penicillin resistance. Cefditoren had MIC50/MIC90 results for Moraxella catarrhalis and Haemophilus influenzae of 0.12/0.5 and < or = 0.008/0.015 microgram/mL, respectively. The pneumococci were consistently twofold to eightfold more susceptible to cefditoren than other oral cephalosporins or penicillins. The MIC90 for penicillin-resistant S. pneumoniae was only 2 micrograms cefditoren/mL, and the highest recorded MIC was 4 micrograms/mL. Cefditoren appears to be a very promising beta-lactam possessing the greatest potency and potential spectrum versus contemporary (1997) respiratory tract pathogens.
Authors:
R N Jones; D J Biedenbach; M A Croco; M S Barrett
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Diagnostic microbiology and infectious disease     Volume:  31     ISSN:  0732-8893     ISO Abbreviation:  Diagn. Microbiol. Infect. Dis.     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1998-11-17     Completed Date:  1998-11-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8305899     Medline TA:  Diagn Microbiol Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  573-8     Citation Subset:  IM    
Affiliation:
Department of Pathology, University of Iowa College of Medicine, Iowa City, USA.
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents / pharmacology
Cephalosporins / pharmacology*
Community-Acquired Infections / microbiology
Haemophilus influenzae / drug effects*,  enzymology
Humans
Microbial Sensitivity Tests
Moraxella (Branhamella) catarrhalis / drug effects*,  enzymology
Penicillin Resistance
Penicillins / pharmacology
Respiratory Tract Infections / microbiology
Streptococcus pneumoniae / drug effects*,  enzymology
beta-Lactamases / metabolism
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Cephalosporins; 0/Penicillins; 104145-95-1/cefditoren; EC 3.5.2.6/beta-Lactamases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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