| In vitro evaluation of magnetic resonance imaging at 3.0 tesla on clonogenic ability, proliferation, and cell cycle in human embryonic lung fibroblasts. | |
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MedLine Citation:
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PMID: 17351426 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: We investigated the influence of magnetic resonance (MR) at 3.0 T on clonogenic ability, proliferation, and cell cycle in an embryonic human cell line. MATERIALS AND METHODS: Cells (human lung fibroblasts Hel 299) were exposed to the static magnetic field (3.0 T) of a magnetic resonance imager (MRI) and to a turbo spin echo sequence at 3.0 T within clinical limitations (specific absorption rate 0.92 W/kg). A special MR-compatible incubation system was used. A control group (sham-exposed) and a MRI group (exposed) were set up. We investigated 3 biologic endpoints: colony forming, cell cycle, and proliferation ability. The exposure time was 2 hours in each experiment. RESULTS: In the statistical analysis, none of these tests showed relevant differences between the exposed and sham-exposed group. CONCLUSIONS: No influences of the static field alone as well as a turbo spin echo sequence at 3.0 T on clonogenic ability, proliferation, or cell cycle in eugenic human lung fibroblasts were found. |
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Authors:
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Nina F Schwenzer; Rüdiger Bantleon; Brigitte Maurer; Rainer Kehlbach; Tina Herberts; Claus D Claussen; Enno Rodegerdts |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Investigative radiology Volume: 42 ISSN: 0020-9996 ISO Abbreviation: Invest Radiol Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-03-12 Completed Date: 2007-05-08 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0045377 Medline TA: Invest Radiol Country: United States |
Other Details:
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Languages: eng Pagination: 212-7 Citation Subset: IM |
Affiliation:
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Department of Diagnostic Radiology, Eberhard-Karls University, Tübingen, Germany. nina.schwenzer@med.uni-tuebingen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Cycle
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physiology* Cell Proliferation* Electromagnetic Fields / adverse effects* Fibroblasts / physiology* Humans Lung / physiology* Magnetic Resonance Imaging / adverse effects, instrumentation* Stem Cells |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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