Document Detail


In vitro evaluation of intestinal fluoride absorption using different cell models.
MedLine Citation:
PMID:  22387159     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The main routes of fluoride (F) exposure are drinking water and certain foods; consequently, intestinal absorption is an important stage in the study of F exposure. In the present study, different cell models [Caco-2, HT29-MTX and various proportions of Caco-2/HT29-MTX)] were used to evaluate intestinal transport of F. The influence of cell type, pH, mucus layer, bile salts and food matrices on the apparent permeability coefficient (P(app)) was evaluated. The results show that a higher proportion of HT29-MTX in the monolayer produces an increase in F permeability, although the mucus layer secreted by HT29-MTX decreases F transport. The results also show that taurocholic acid, a component of bile salts, and acid pH increase F permeability, whereas the presence of a food matrix (rice) decreases intestinal transport of F. In all cases, alterations in F permeability were closely related with modulation of cell junctions.
Authors:
R A Rocha; D Vélez; V Devesa
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-28
Journal Detail:
Title:  Toxicology letters     Volume:  -     ISSN:  1879-3169     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-3-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7709027     Medline TA:  Toxicol Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Ireland Ltd.
Affiliation:
Instituto de Agroquímica y Tecnología de Alimentos (CSIC), Avenida Agustín Escardino, n° 7, 46980 - Paterna (Valencia), Spain.
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