| In vitro evaluation of dual mode ultrasonic thrombolysis method for transcranial application with an occlusive thrombosis model. | |
| | |
MedLine Citation:
|
PMID: 17854979 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A recent clinical trial of transcranial low-frequency ultrasound-mediated tPA thrombolysis (LFUT) showed cerebral hemorrhages associated with high spatial peak pulse average intensity (I(SPPA)), wide beam and long pulse duration. We developed an alternative approach to LFUT wherein diagnostic power M-mode Doppler (PMD) ultrasound is combined with LFUT, with a goal of increased safety. The effectiveness of such a dual mode ultrasonic thrombolysis (DMUT) was explored in vitro. The DMUT system emitted PMD (2 MHz) and LFUT (550 kHz) beams in alternating fashion from a small 12 mm diameter probe. The LFUT had a low I(SPPA) (2 W/cm(2)) and a short pulse duration (55 micros). Occlusive clots made in plastic tips from bovine plasma and thrombin were placed in flow models pressurized to 800 mH(2)O, with 600 IU/mL monteplase injected upstream. Recanalization times were then compared among three groups: the control (monteplase alone), PMD (monteplase + PMD) and DMUT (monteplase + PMD + LFUT). The capability of the DMUT device to monitor recanalization was demonstrated by observing with Doppler the degree of flow of a blood-mimicking fluid in the vicinity of the clot. Recanalization times were 37.9 +/- 22.9, 38.9 +/- 12.4 and 18.5 +/- 8.0 min, respectively, for the control, PMD and DMUT. There were significant differences between DMUT and the control (p = 0.0004) and between DMUT and PMD (p = 0.0004). Recanalization flows were clearly detected. It is anticipated that this DMUT method presents a safer and more efficient approach than normal LFUT. |
| | |
Authors:
|
Zuojun Wang; Mark A Moehring; Arne H Voie; Hiroshi Furuhata |
Related Documents
:
|
7547739 - Obstetric antecedents of surgically treated obstetric brachial plexus injuries. 18185079 - Survival and neurodevelopmental outcomes of preterm infants. 7362489 - Periventricular leukomalacia. a one-year autopsy study. 10992199 - Magnesium sulfate for tocolysis and risk of spastic cerebral palsy in premature childre... 7831979 - Prognosis in infants with birth asphyxia. 12904589 - Cbf reactivity in hypotensive and normotensive preterm infants. 15993729 - The development and implementation of a multidisciplinary neonatal resuscitation team i... 10545549 - Early perinatal hospital discharge and parenting during infancy. 3585439 - Continuous neonatal evaluation in the delivery room by pulse oximetry. |
Publication Detail:
|
Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't Date: 2007-09-14 |
Journal Detail:
|
Title: Ultrasound in medicine & biology Volume: 34 ISSN: 0301-5629 ISO Abbreviation: Ultrasound Med Biol Publication Date: 2008 Jan |
Date Detail:
|
Created Date: 2007-12-18 Completed Date: 2008-04-30 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0410553 Medline TA: Ultrasound Med Biol Country: England |
Other Details:
|
Languages: eng Pagination: 96-102 Citation Subset: IM |
Affiliation:
|
Medical Engineering Laboratory, Research Center for Medical Science, Jikei University School of Medicine, Tokyo, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cattle Humans Intracranial Thrombosis / therapy*, ultrasonography Models, Anatomic Plasminogen Activators / therapeutic use Thrombolytic Therapy / methods* Treatment Outcome Ultrasonic Therapy / methods* Ultrasonography, Doppler, Transcranial |
| Chemical | |
Reg. No./Substance:
|
0/monteplase; EC 3.4.21.-/Plasminogen Activators |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The distance between state and rural society in the PRC. Reading document no 1 (February 2004).
Next Document: Real-time myocardial contrast echocardiography for assessing perfusion and function in healthy and i...