Document Detail


In vitro evaluation of ceftibuten (7432-S, SCH 39720), a novel orally administered cephalosporin.
MedLine Citation:
PMID:  3147148     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
7432-S (SCH 39720) was the most active beta-lactam tested against the Enterobacteriaceae, inhibiting 92% of strains at less than or equal to 8.0 micrograms/ml compared to 82%, 65% and 39% of strains inhibited by cefixime, cefuroxime and cefaclor, respectively. 7432-S was also very effective against Haemophilus influenzae (MIC90, less than or equal to 0.25 microgram/ml), Branhamella catarrhalis (MIC90, 4.0 micrograms/ml) and Neisseria meningitidis (MIC90, less than or equal to 0.25 microgram/ml). Serogroup B streptococci and the penicillin-resistant pneumococci were generally less susceptible to 7432-S and comparison cephems than Streptococcus pyogenes or penicillin-susceptible S. pneumoniae isolates. Pseudomonas spp., enterococci, Acinetobacter spp. and Staphylococcus spp. were routinely resistant to 7432-S (MIC50s, greater than or equal to 32 micrograms/ml).
Authors:
R N Jones; A L Barry
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Chemioterapia : international journal of the Mediterranean Society of Chemotherapy     Volume:  7     ISSN:  0392-906X     ISO Abbreviation:  Chemioterapia     Publication Date:  1988 Oct 
Date Detail:
Created Date:  1989-03-29     Completed Date:  1989-03-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8401667     Medline TA:  Chemioterapia     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  283-6     Citation Subset:  IM    
Affiliation:
Clinical Microbiology Institute, Tualatin, Oregon 97062.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Cefaclor / pharmacology
Cefixime
Cefotaxime / analogs & derivatives,  pharmacology
Cefuroxime / pharmacology
Cephalexin / pharmacology
Cephalosporins / analogs & derivatives*,  pharmacology
Enterobacteriaceae / drug effects*
Haemophilus influenzae / drug effects
Microbial Sensitivity Tests
Moraxella (Branhamella) catarrhalis / drug effects
Neisseria meningitidis / drug effects
Streptococcus / drug effects
Chemical
Reg. No./Substance:
0/Cephalosporins; 15686-71-2/Cephalexin; 53994-73-3/Cefaclor; 55268-75-2/Cefuroxime; 63527-52-6/Cefotaxime; 79350-37-1/Cefixime; 97519-39-6/ceftibuten

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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