Document Detail

In vitro evaluation of antibacterial, anticollagenase, and antioxidant activities of hop components (Humulus lupulus) addressing acne vulgaris.
MedLine Citation:
PMID:  19201179     Owner:  NLM     Status:  MEDLINE    
Seven naturally derived components from hop plant (Humulus lupulus L.) extracts were tested for evaluation of biological activities affecting acne vulgaris. Five strains, Propionibacterium acnes, Staphylococcus epidermidis, Staphylococcus aureus, Kocuria rhizophila and, Staphylococcus pyogenes, were selected as the main acne-causing bacteria. Hop extracts xanthohumol and the lupulones showed strong inhibitory activities against all of the strains. Although hydrogenated derivatives did not show the same level of activity, naturally occurring xanthohumol, humulones, and lupulones all showed moderate to strong anticollagenase inhibitory activities. Antioxidant capacity was also evaluated with seven different methods based on different reactive oxygen species. Xanthohumol showed the highest activity in total oxygen radical absorbance capacity as well as singlet oxygen absorbance capacity.
Naoto Yamaguchi; Keiko Satoh-Yamaguchi; Mitsunori Ono
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Publication Detail:
Type:  Journal Article     Date:  2009-02-06
Journal Detail:
Title:  Phytomedicine : international journal of phytotherapy and phytopharmacology     Volume:  16     ISSN:  1618-095X     ISO Abbreviation:  Phytomedicine     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-24     Completed Date:  2009-05-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9438794     Medline TA:  Phytomedicine     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  369-76     Citation Subset:  IM    
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MeSH Terms
Acne Vulgaris* / drug therapy
Actinobacteria / drug effects
Anti-Bacterial Agents / pharmacology*
Antioxidants / pharmacology*
Bacteria / drug effects*
Biphenyl Compounds / adverse effects
Collagenases / antagonists & inhibitors*
Cyclohexenes / pharmacology
Matrix Metalloproteinase 1 / metabolism
Matrix Metalloproteinase 8 / metabolism
Microbial Sensitivity Tests
Picrates / adverse effects
Plant Extracts / pharmacology*
Propionibacterium acnes / drug effects
Propiophenones / pharmacology
Staphylococcus / drug effects
Terpenes / pharmacology
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Antioxidants; 0/Biphenyl Compounds; 0/Cyclohexenes; 0/Picrates; 0/Plant Extracts; 0/Propiophenones; 0/Terpenes; 1898-66-4/2,2-diphenyl-1-picrylhydrazyl; 468-28-0/lupulon; 469-02-3/humulon; 6754-58-1/xanthohumol; EC 3.4.24.-/Collagenases; EC Metalloproteinase 8; EC Metalloproteinase 1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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