| In vitro evaluation of alternative oral contrast agents for MRI of the gastrointestinal tract. | |
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MedLine Citation:
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PMID: 17485189 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: In vitro evaluation of different materials as potential alternative oral contrast agents for small bowel MRI. MATERIALS AND METHODS: The T1 and T2 relaxation times of rose hip syrup, black currant extract, cocoa, iron-deferoxamine solution and a commonly used oral contrast material (1 mM Gd-DTPA) were determined in vitro at different concentrations on a 1.0 T clinical MR scanner. T1 values were obtained with an inversion prepared spoiled gradient echo sequence. T2 values were obtained using multiple echo sequences. Finally the materials were visualized on T1-, T2- and T2*-weighted MR images. RESULTS: The relaxation times of the undiluted rose hip syrup (T1=110+/-5 ms, T2=86+/-3 ms), black currant extract (T1=55+/-3 ms, T2=39+/-2 ms) and 5 mM iron-deferoxamine solution (T1=104+/-4 ms, T2=87+/-2 ms) were much shorter than for a 1mM Gd-DTPA solution (T1=180+/-8 ms, T2=168+/-5 ms). Dilution of black currant extract to 30% or a 3 mM iron-deferoxamine solution conducted to T1 relaxation times which are quite comparable to a 1 mM Gd-DTPA solution. Despite its much lower metal content an aqueous cocoa suspension (100 g/L) produced T2 relaxation times (T1=360+/-21 ms, T2=81+/-3 ms) more or less in the same range like the 5 mM iron-deferoxamine solution. Imaging of our in vitro model using clinical sequences allowed to anticipate the T1-, T2- and T2*-depiction of all used substances. Cocoa differed from all other materials with its low to moderate signal intensity on T1- and T2-weighted sequences. While all substances presented a linear 1/T1 and 1/T2 relationship towards concentration, rose hip syrup broke ranks with a disproportionately high increase of relaxation at higher concentrations. CONCLUSIONS: Rose hip syrup, black currant extract and iron-deferoxamine solution due to their positive T1 enhancement characteristics and drinkability appear to be valuable oral contrast agents for T1-weighted small bowel MRI. Cocoa with its differing relaxation and signal enhancement properties is a promising oral contrast agent but needs further clinical evaluation. |
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Authors:
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Magor Babos; Attila Schwarcz; Manjit Singh Randhawa; Balázs Marton; Lilla Kardos; András Palkó |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article Date: 2007-05-07 |
Journal Detail:
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Title: European journal of radiology Volume: 65 ISSN: 0720-048X ISO Abbreviation: Eur J Radiol Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2008-01-08 Completed Date: 2008-04-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8106411 Medline TA: Eur J Radiol Country: Ireland |
Other Details:
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Languages: eng Pagination: 133-9 Citation Subset: IM |
Affiliation:
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University of Szeged, Faculty of Science, Hungary. babosmagor@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Cacao / chemistry Contrast Media / chemistry* Deferoxamine / chemistry Gadolinium DTPA / chemistry Gastrointestinal Diseases / diagnosis* Humans Magnetic Resonance Imaging / methods* Plant Extracts / chemistry Regression Analysis Ribes / chemistry Rosa / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Plant Extracts; 70-51-9/Deferoxamine; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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