Document Detail

In vitro effects of inosine-pyruvate-phosphate on P50 values and DPG contents of fresh and stored blood from healthy neonates, symptom-free premature infants and premature infants with respiratory distress syndrome.
MedLine Citation:
PMID:  26433     Owner:  NLM     Status:  MEDLINE    
A study was made of the effect of a 3-hour incubation with inosine-pyruvate-phosphate (IPP) on the P50 values and 2,3-DPG contents of fresh blood and blood which had stood for 96 h, from healthy adults, term neonates, 1-2-week-old symptom-free premature infants and RDS premature infants. It was found that the P50 value and the 2,3-DPG content could be increased considerably by IPP treatment in both the fresh and the stood blood in the various groups of neonates. The question remains open as to whether the effect of IPP, in significantly improving the O2 transport in neonates, is a consequence of the 2,3-DPG alone or of some other metabolite. In RDS the stimulating effect of the IPP mixture is appreciably lower.
D Boda; E Eck
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biology of the neonate     Volume:  33     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1978  
Date Detail:
Created Date:  1978-09-01     Completed Date:  1978-09-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  25-30     Citation Subset:  IM    
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MeSH Terms
Diphosphoglyceric Acids / blood*
Hydrogen-Ion Concentration*
Infant, Newborn
Infant, Premature*
Inosine Nucleotides / pharmacology*
Oxygen / blood*
Pyruvates / pharmacology*
Respiratory Distress Syndrome, Newborn / blood*
Reg. No./Substance:
0/Diphosphoglyceric Acids; 0/Inosine Nucleotides; 0/Pyruvates; 7782-44-7/Oxygen

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