Document Detail


In vitro effects of flavone from leaves of Diospyros kaki on rat cardiac myocyte apoptosis induced by hypoxia-reoxygenation and advanced glycation end products.
MedLine Citation:
PMID:  12865219     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate the effects of flavone extracted from the leaves of Diospyros kaki on the apoptosis of rat cardiac myocytes induced by hypoxia-reoxygenation and advanced glycation end products in vitro. METHODS: The cardiac myocytes were isolated from neonatal SD rats and cultured in vitro for 72 h. Apoptosis of the cultured cells was induced by hypoxia-reoxygenation and advanced glycation end products (AGEs) respectively, and the effects of flavone extracted from the leaves of Diospyros kaki on the cell apoptosis was observed by measuring the apoptotic rates using flow cytometry. RESULTS: Apoptosis of neonatal rat cardiac myocytes was induced by hypoxia-reoxygenation in a time-dependent manner (6.05% +/-0.46% vs 12.45% +/-1.66%, P< 0.05), and flavone treatment of the cells significantly lowered the apoptotic rates. AGEs alone also induced apoptosis of neonatal rat cardiac myocytes (11.03+/-0.39 vs 6.25+/-0.48, P< 0.05), which was inhibited by flavone (8.40+/-0.47 vs 11.03+/-0.39, P < 0.05). CONCLUSION: Flavone extracted from the leaves of Diospyros kaki can inhibit the apoptosis of in vitro cultured neonatal rat cardiac myocytes induced by hypoxia-reoxygenation and advanced glycation end products.
Authors:
Ping Ouyang; Wei-jJian Bei; Wen-yan Lai; Ding-li Xu; Wen-lie Peng
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA     Volume:  23     ISSN:  1000-2588     ISO Abbreviation:  Di Yi Jun Yi Da Xue Xue Bao     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-07-16     Completed Date:  2004-01-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9426110     Medline TA:  Di Yi Jun Yi Da Xue Xue Bao     Country:  China    
Other Details:
Languages:  eng     Pagination:  680-2     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China. ouyp@msn.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis / drug effects*
Cell Hypoxia*
Diospyros / chemistry*
Female
Flavonoids / pharmacology*
Glycosylation End Products, Advanced / toxicity*
Male
Myocytes, Cardiac / drug effects*,  pathology
Plant Leaves / chemistry
Rats
Rats, Sprague-Dawley
Chemical
Reg. No./Substance:
0/Flavonoids; 0/Glycosylation End Products, Advanced

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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