| In vitro effects of calcium fructoborate on fMLP-stimulated human neutrophil granulocytes. | |
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MedLine Citation:
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PMID: 17848728 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Discovery of naturally occurring boron complexes with organic compounds containing hydroxyl groups, sugars, and polysaccharides, adenosine-5-phosphate, pyridoxine, riboflavin, dehydroascorbic acid, and pyridine nucleotides led to the reassessment of the biochemical role of boron. Boron's anti-inflammatory actions were claimed but not yet demonstrated. This study investigated the effects of calcium fructoborate (CF) on the human polymorphonuclear neutrophils (PMN) that play a central role in the inflammatory response. Our results demonstrated that CF exposure induced a dose-dependent decrease in cell viability. Treatment of PMN cells, for 24 h, with 22,500 microM CF led to a decrease in cell viability by 61.1%, an inhibition of respiratory burst by 92.9% in the case of fMLP-stimulated cells, a diminution of intracellular level of superoxide anion with 59.3%, and a stimulation of superoxide dismutase activity by 72% in unstimulated PMN cells. Altogether, these results suggest the antioxidant and anti-inflammatory properties of CF. |
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Authors:
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R Scorei; Raluca Ciubar; Cristina Iancu; Valentina Mitran; Anisoara Cimpean; Dana Iordachescu |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biological trace element research Volume: 118 ISSN: 0163-4984 ISO Abbreviation: Biol Trace Elem Res Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-09-12 Completed Date: 2007-10-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7911509 Medline TA: Biol Trace Elem Res Country: United States |
Other Details:
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Languages: eng Pagination: 27-37 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, University of Craiova, 13 A.I. Cuza, Craiova, 200585, Romania. romulus_ion@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Inflammatory Agents / pharmacology Antioxidants / pharmacology Apoptosis / physiology Borates / pharmacology* Calcium Chloride / pharmacology Cell Survival Dose-Response Relationship, Drug Fructose / analogs & derivatives*, pharmacology Humans N-Formylmethionine Leucyl-Phenylalanine / pharmacology* Neutrophils / drug effects*, metabolism Respiratory Burst Superoxide Dismutase / metabolism Superoxides / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Antioxidants; 0/Borates; 0/calcium fructoborate; 10043-52-4/Calcium Chloride; 11062-77-4/Superoxides; 1330-43-4/sodium borate; 30237-26-4/Fructose; 59880-97-6/N-Formylmethionine Leucyl-Phenylalanine; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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