Document Detail

In vitro effects of Chelidonium majus L. alkaloid thiophosphoric acid conjugates (Ukrain) on the phenotype of normal human lymphocytes.
MedLine Citation:
PMID:  1305038     Owner:  NLM     Status:  MEDLINE    
Several plant-derived drugs are used in medical oncology (1-3). The thiophosphoric acid-alkaloid derivative from the plant Chelidonium majus L. (Ukrain) has been produced since 1978 by Nowicky. (Austrian Patent No. 354644, Vienna, 25 January 1980). It has been reported that this drug may exert therapeutic effects in cancer patients by modulating their immune systems (4, 5-8). The aim of this study was to evaluate in vitro the possibility that Ukrain may influence the phenotype of lymphocyte subpopulations isolated from healthy donors.
B Slesak; J W Nowicky; A Harłozinska
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Drugs under experimental and clinical research     Volume:  18 Suppl     ISSN:  0378-6501     ISO Abbreviation:  Drugs Exp Clin Res     Publication Date:  1992  
Date Detail:
Created Date:  1993-07-12     Completed Date:  1993-07-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7802135     Medline TA:  Drugs Exp Clin Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  17-21     Citation Subset:  IM    
Department of Tumour Immunology, Silesian Piast's Medical Academy, Wrocław, Poland.
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MeSH Terms
Alkaloids / pharmacology*
Berberine Alkaloids
Lymphocytes / drug effects*
T-Lymphocytes, Helper-Inducer / drug effects
T-Lymphocytes, Regulatory / drug effects
Reg. No./Substance:
0/Alkaloids; 0/Berberine Alkaloids; 0/Phenanthridines; 0/ukrain

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