Document Detail


In vitro effect of suramin on lung tumour cells.
MedLine Citation:
PMID:  8422289     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the search for new therapeutic concepts in lung cancer chemotherapy, suramin, a potential anticancer drug which evades multidrug resistance, was tested in vitro on 25 lung-derived cell lines, either non-tumorigenic cells, or established cell lines from five different tumour types. Suramin treatment resulted in a time- and dose-dependent decrease in [3H]thymidine incorporation, except in one adenocarcinoma cell line where DNA synthesis was highly stimulated. [3H]Leucine incorporation was less affected, indicating that suramin acted cytostatically rather than cytotoxically. Our results show that suramin affected DNA synthesis of the different types of lung derived cells, including non-tumorigenic and tumour cell lines, to a similar extent.
Authors:
I A Mórocz; B Lauber; D Schmitter; R A Stahel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of cancer (Oxford, England : 1990)     Volume:  29A     ISSN:  0959-8049     ISO Abbreviation:  Eur. J. Cancer     Publication Date:  1993  
Date Detail:
Created Date:  1993-02-23     Completed Date:  1993-02-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9005373     Medline TA:  Eur J Cancer     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  245-7     Citation Subset:  IM    
Affiliation:
Department of Medicine, University Hospital, Zürich, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
DNA, Neoplasm / biosynthesis
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Humans
Leucine / metabolism
Lung Neoplasms / drug therapy*,  metabolism
Suramin / therapeutic use*
Thymidine / metabolism
Time Factors
Tumor Cells, Cultured / drug effects
Chemical
Reg. No./Substance:
0/DNA, Neoplasm; 145-63-1/Suramin; 50-89-5/Thymidine; 61-90-5/Leucine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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