Document Detail


In vitro effect of quercetin on human gastric carcinoma: Targeting cancer cells death and MDR.
MedLine Citation:
PMID:  22750388     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The benefits of plant polyphenols as chemotherapeutic agents are of great interest due to their possible anti-cancerogenic activities. Results available up to now suggest that flavonoid quercetin induces lethal effect in many types of tumours and may sensitize resistant cells to drugs. The aim of the study was to examine the effect of quercetin on human gastric carcinoma cells and to determine mode of its action. Parental EPG85-257P cell line and its daunorubicin-resistant variant EPG85-257RDB were used as cell models. Our data revealed that quercetin exerted antyproliferative impact on studied cells (with IC(50) value of 12 μM after 72h), mainly through induction of apoptosis. In sensitive cells cytostatic drug and flavonoid had synergistic effects, in EPG85-257RDB cells quercetin acted as a chemosensitizer. Its impact on resistance mechanism involved decrease of P-glycoprotein expression, inhibition of drug transport and downregulation of ABCB1 gene. The results demonstrate that quercetin may be considered as a prospective drug to overcome classical resistance in gastric cancer cells.
Authors:
Sylwia Borska; Magdalena Chmielewska; Teresa Wysocka; Malgorzata Drag-Zalesinska; Maciej Zabel; Piotr Dziegiel
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-29
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  -     ISSN:  1873-6351     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-7-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Ltd.
Affiliation:
Department of Histology and Embryology, Medical University, Chalubinskiego 6a, 50-368 Wroclaw, Poland.
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